Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide

Prolonged exposure of cultured cortical cells or cultured cerebellar granule cells to the residue 25-35 fragment of beta-amyloid peptide (beta AP), beta AP(25-35), induced neuronal apoptosis, as revealed by morphological analysis, fluorescent chromatin staining, and immunodetection of oligonucleosom...

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Veröffentlicht in:	Molecular pharmacology 1995-05, Vol.47 (5), p.890
Hauptverfasser:	Copani, A, Bruno, V, Battaglia, G, Leanza, G, Pellitteri, R, Russo, A, Stanzani, S, Nicoletti, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobutyrates - pharmacology Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - pharmacology Amyloid beta-Peptides - toxicity Animals Apoptosis - drug effects Apoptosis - physiology Benzoates - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Cells, Cultured Cerebellum - cytology Cerebellum - drug effects Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Glycine - analogs & derivatives Glycine - pharmacology Mice Nerve Degeneration - drug effects Nerve Degeneration - physiology Neurons - drug effects Neurons - metabolism Peptide Fragments - antagonists & inhibitors Peptide Fragments - pharmacology Peptide Fragments - toxicity Phosphoserine - pharmacology Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - metabolism
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