CARCINOGENIC EFFECT OF 1-BUTYL-1-NITROSOUREA ON FEMALE SPRAGUE-DAWLEY RATS

Carcinogenic effect of a single oral administration of 300 or 200mg/kg body weight of 1-butyl-1-nitrosourea (BNU) and continuous oral administration of 400ppm solution of BNU in the drinking water for 5, 10, 15, and 20 weeks to female SD rats was studied. In addition, the number of spleen cells capa...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1975/12/31, Vol.66(6), pp.615-621
Hauptverfasser:	ODASHIMA, Shigeyoshi, HASHIMOTO, Yoshiyuki, OGIU, Toshiaki, MAEKAWA, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Butyl-1-nitrosourea Adenocarcinoma, Papillary - chemically induced Adenocarcinoma, Papillary - pathology Administration, Oral Animals Antibody-Producing Cells Carcinogenesis, chemical Carcinogens Dose-Response Relationship, Drug Female Hemolytic Plaque Technique Intestinal Neoplasms - chemically induced Leukemia, Experimental - chemically induced Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - pathology Neoplasms, Experimental Nitrosourea Compounds - administration & dosage Ovarian Neoplasms - chemically induced Rats Sprague-Dawley rats Stomach Neoplasms - chemically induced
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