Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes

We have used immunocytochemical analyses to characterize the subcellular distribution of protein kinase C (PKC)-alpha, -beta I, -beta II, -gamma, -delta, -epsilon, -zeta, and -eta in NIH 3T3 fibroblasts that overexpress these different PKC isozymes. Immunofluorescence studies and Western blotting wi...

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Veröffentlicht in:	The Journal of biological chemistry 1995-04, Vol.270 (17), p.9991
Hauptverfasser:	Goodnight, J A, Mischak, H, Kolch, W, Mushinski, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Actin Cytoskeleton - enzymology Actins - metabolism Animals Antibody Specificity Biological Transport Cell Membrane - enzymology Cell Nucleus - enzymology Cloning, Molecular Endoplasmic Reticulum - enzymology Enzyme Activation Fibroblasts - enzymology Golgi Apparatus - enzymology Immunohistochemistry Intracellular Membranes - enzymology Isoenzymes - genetics Isoenzymes - immunology Isoenzymes - metabolism Mice Protein Kinase C - genetics Protein Kinase C - immunology Protein Kinase C - metabolism Subcellular Fractions - enzymology Tetradecanoylphorbol Acetate - pharmacology
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