Experimental study on mechanism of steroid-induced avascular necrosis of femoral head

Experimental study on mechanism of steroid-induced avascular necrosis of femoral head

The authors adopted an animal model to observe the pathogenic mechanism of steroid-induced avascular necrosis of the femoral head. Sixty-four white rabbits were divided into two groups: hydrocortisone acetate (8 mg/kg) was hypodermically given to 48 experimental animals and 0.32 mg/kg of normal sali...

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Veröffentlicht in:Chung-hua wai kʿo tsa chih 1994-09, Vol.32 (9), p.515
Hauptverfasser: Wang, K Z, Mao, L Z, Hu, C G
Format: Artikel
Sprache:chi
Schlagworte:
Animals
Femur Head - pathology
Femur Head - ultrastructure
Femur Head Necrosis - chemically induced
Femur Head Necrosis - pathology
Hydrocortisone
Rabbits
Random Allocation
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container_title Chung-hua wai kʿo tsa chih
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creator Wang, K Z
Mao, L Z
Hu, C G
description The authors adopted an animal model to observe the pathogenic mechanism of steroid-induced avascular necrosis of the femoral head. Sixty-four white rabbits were divided into two groups: hydrocortisone acetate (8 mg/kg) was hypodermically given to 48 experimental animals and 0.32 mg/kg of normal saline to 16 rabbits for control. Two groups of animals were fed and kept in the same condition. The results showed that application of the steroid drug could produce fat degeneration and necrosis of osteocytes and fat embolism in the small blood vessels of the femoral head. The abnormal hypertrophied fat cells in the bone marrow compressed small veins in the femoral head resulting in blood stasis of the capillaries, thus growth and regeneration of the capillary were inhibited.
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The abnormal hypertrophied fat cells in the bone marrow compressed small veins in the femoral head resulting in blood stasis of the capillaries, thus growth and regeneration of the capillary were inhibited.</description><identifier>ISSN: 0529-5815</identifier><identifier>PMID: 7720417</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Femur Head - pathology ; Femur Head - ultrastructure ; Femur Head Necrosis - chemically induced ; Femur Head Necrosis - pathology ; Hydrocortisone ; Rabbits ; Random Allocation</subject><ispartof>Chung-hua wai kʿo tsa chih, 1994-09, Vol.32 (9), p.515</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7720417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, K Z</creatorcontrib><creatorcontrib>Mao, L Z</creatorcontrib><creatorcontrib>Hu, C G</creatorcontrib><title>Experimental study on mechanism of steroid-induced avascular necrosis of femoral head</title><title>Chung-hua wai kʿo tsa chih</title><addtitle>Zhonghua Wai Ke Za Zhi</addtitle><description>The authors adopted an animal model to observe the pathogenic mechanism of steroid-induced avascular necrosis of the femoral head. 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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Animals
Femur Head - pathology
Femur Head - ultrastructure
Femur Head Necrosis - chemically induced
Femur Head Necrosis - pathology
Hydrocortisone
Rabbits
Random Allocation
title Experimental study on mechanism of steroid-induced avascular necrosis of femoral head
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