Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells

The present study was designed to evaluate the effect of the activation of bradykinin (BK) receptors on intracellular cAMP levels in isolated glomeruli as well as in cultured rat mesangial cells. BK affected basal cAMP content only in the presence of the phosphodiesterase inhibitor isobutylmethylxan...

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Veröffentlicht in:	Molecular pharmacology 1993-10, Vol.44 (4), p.818-826
Hauptverfasser:	BASCANDS, J.-L, PECHER, C, GIROLAMI, J.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Adenylate Cyclase Toxin Adenylyl Cyclases - metabolism Animals Biological and medical sciences Bradykinin - pharmacology Cells, Cultured Colforsin - antagonists & inhibitors Colforsin - pharmacology Cyclic AMP - biosynthesis Diglycerides - biosynthesis Diglycerides - pharmacology Dinoprostone - pharmacology Down-Regulation - drug effects Down-Regulation - physiology Drug Interactions Enzyme Activation Fundamental and applied biological sciences. Psychology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Isoproterenol - pharmacology Kidney Glomerulus - cytology Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Male Pertussis Toxin Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Quinacrine - pharmacology Rats Rats, Sprague-Dawley Receptors, Bradykinin - drug effects Receptors, Bradykinin - physiology Stimulation, Chemical Tetradecanoylphorbol Acetate - pharmacology Vertebrates: urinary system Virulence Factors, Bordetella - pharmacology
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