Altered Synaptic Plasticity and Memory Formation in Nitric Oxide Synthase Inhibitor-Treated Rats

Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term potentiation (LTP). Since LTP is a form of synaptic plasticity thought to be involved in learning and memory,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-10, Vol.90 (19), p.9191-9194
Hauptverfasser:	BÖHME, G. A, BON, C, LEMAIRE, M, REIBAUD, M, PIOT, O, STUTZMANN, J.-M, DOBLE, A, BLANCHARD, J.-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - antagonists & inhibitors Animals Arginine - analogs & derivatives Arginine - pharmacology Avoidance Learning - drug effects Behavioral psychophysiology Biological and medical sciences Computer memory Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - enzymology Hippocampus - physiology In Vitro Techniques Learning Learning - drug effects Learning rate Long term potentiation Male Mazes Medical research Memory Memory - drug effects Memory - physiology Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons Neurotransmission and behavior Nitric Oxide Synthase Nitroarginine Oxides Pretreatment Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Random access memory Rats Rats, Sprague-Dawley Rats, Wistar Rodents Smell Social Behavior Space Perception Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Time Factors
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