Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis
Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides an indirect measure of repair. We report the results of...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1993-07, Vol.2 (4), p.329 |
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| creator | Spitz, M R Fueger, J J Halabi, S Schantz, S P Sample, D Hsu, T C |
| description | Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic
exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides
an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing
differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers
and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer
Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell
> or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and
heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the
combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect
(OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm
those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering
interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures. |
| format | Article |
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exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides
an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing
differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers
and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer
Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell
> or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and
heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the
combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect
(OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm
those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering
interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 7688625</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Alcohol Drinking - adverse effects ; Bleomycin - adverse effects ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; Chromosome Aberrations - genetics ; Chromosomes - drug effects ; Disease Susceptibility ; DNA Damage ; Female ; Humans ; Laryngeal Neoplasms - etiology ; Laryngeal Neoplasms - genetics ; Male ; Middle Aged ; Mouth Neoplasms - etiology ; Mouth Neoplasms - genetics ; Mutagens - adverse effects ; Odds Ratio ; Pharyngeal Neoplasms - etiology ; Pharyngeal Neoplasms - genetics ; Plants, Toxic ; Risk Factors ; Smoking - adverse effects ; Tobacco, Smokeless - adverse effects</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1993-07, Vol.2 (4), p.329</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7688625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spitz, M R</creatorcontrib><creatorcontrib>Fueger, J J</creatorcontrib><creatorcontrib>Halabi, S</creatorcontrib><creatorcontrib>Schantz, S P</creatorcontrib><creatorcontrib>Sample, D</creatorcontrib><creatorcontrib>Hsu, T C</creatorcontrib><title>Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic
exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides
an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing
differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers
and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer
Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell
> or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and
heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the
combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect
(OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm
those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering
interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures.</description><subject>Alcohol Drinking - adverse effects</subject><subject>Bleomycin - adverse effects</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>Chromosome Aberrations - genetics</subject><subject>Chromosomes - drug effects</subject><subject>Disease Susceptibility</subject><subject>DNA Damage</subject><subject>Female</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - etiology</subject><subject>Laryngeal Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - etiology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mutagens - adverse effects</subject><subject>Odds Ratio</subject><subject>Pharyngeal Neoplasms - etiology</subject><subject>Pharyngeal Neoplasms - genetics</subject><subject>Plants, Toxic</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Tobacco, Smokeless - adverse effects</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj8FKxDAURYMo4zj6CUJW7gppktc27mRQRxjRha7La_o6jXTakmSU_r2FzuoeOHC594KtU1BFkucAlzMLgMSYDK7ZTQg_QojcAKzYKs-KIpOwZp_vp4gH6nmgPrjofl2cuOv5aRzJcyQ_1O5AYRbEo0cbucXekn_kOFOgxA599EPHscduCi7csqsGu0B359yw75fnr-0u2X-8vm2f9kkrVR4TiSkISklXOrWom2aeprHQssmkRsA6002hUNVQGRRpaqypTS0yJTBvKqjUht0vveOpOlJdjt4d0U_l-dnsHxbfukP75zyVy3BPgdDbtpSlLpU06h_vDlnq</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Spitz, M R</creator><creator>Fueger, J J</creator><creator>Halabi, S</creator><creator>Schantz, S P</creator><creator>Sample, D</creator><creator>Hsu, T C</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19930701</creationdate><title>Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis</title><author>Spitz, M R ; Fueger, J J ; Halabi, S ; Schantz, S P ; Sample, D ; Hsu, T C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-2a150e1e4b41ca4ff0074a842f624a5ad64f83a3d5b9a0119c9d9d0630a7fb5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Alcohol Drinking - adverse effects</topic><topic>Bleomycin - adverse effects</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>Chromosome Aberrations - genetics</topic><topic>Chromosomes - drug effects</topic><topic>Disease Susceptibility</topic><topic>DNA Damage</topic><topic>Female</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - etiology</topic><topic>Laryngeal Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - etiology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mutagens - adverse effects</topic><topic>Odds Ratio</topic><topic>Pharyngeal Neoplasms - etiology</topic><topic>Pharyngeal Neoplasms - genetics</topic><topic>Plants, Toxic</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Tobacco, Smokeless - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spitz, M R</creatorcontrib><creatorcontrib>Fueger, J J</creatorcontrib><creatorcontrib>Halabi, S</creatorcontrib><creatorcontrib>Schantz, S P</creatorcontrib><creatorcontrib>Sample, D</creatorcontrib><creatorcontrib>Hsu, T C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spitz, M R</au><au>Fueger, J J</au><au>Halabi, S</au><au>Schantz, S P</au><au>Sample, D</au><au>Hsu, T C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>2</volume><issue>4</issue><spage>329</spage><pages>329-</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic
exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides
an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing
differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers
and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer
Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell
> or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and
heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the
combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect
(OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm
those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering
interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>7688625</pmid></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 1993-07, Vol.2 (4), p.329 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alcohol Drinking - adverse effects Bleomycin - adverse effects Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - genetics Case-Control Studies Chromosome Aberrations - genetics Chromosomes - drug effects Disease Susceptibility DNA Damage Female Humans Laryngeal Neoplasms - etiology Laryngeal Neoplasms - genetics Male Middle Aged Mouth Neoplasms - etiology Mouth Neoplasms - genetics Mutagens - adverse effects Odds Ratio Pharyngeal Neoplasms - etiology Pharyngeal Neoplasms - genetics Plants, Toxic Risk Factors Smoking - adverse effects Tobacco, Smokeless - adverse effects |
| title | Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis |
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