Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Complexed with Double-Stranded DNA at 3.0 Å Resolution Shows Bent DNA

The crystal structure of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) heterodimer (p66/p51), a 19-base/18-base double-stranded DNA template-primer, and a monoclonal antibody Fab fragment has been determined at 3.0 Å resolution. The four individual subdoma...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-07, Vol.90 (13), p.6320-6324
Hauptverfasser:	Jacobo-Molina, Alfredo, Ding, Jianping, Nanni, Raymond G., Clark, Arthur D., Lu, Xiaode, Tantillo, Chris, Williams, Roger L., Kamer, Greg, Ferris, Andrea L., Clark, Patrick, Hizi, Amnon, Hughes, Stephen H., Arnold, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites AIDS/HIV Base Sequence Biochemistry Biological and medical sciences Computer Graphics Crystallization Datasets Deoxyribonucleic acid DNA DNA - chemistry Electron density Enzymes Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Reverse Transcriptase Human immunodeficiency virus Models, Molecular Molecular biophysics Molecular Sequence Data Nucleic Acid Conformation Nucleic acids Nucleotides Protein Conformation Protein Folding Protein Structure, Secondary Ribonuclease H - metabolism RNA-Directed DNA Polymerase - chemistry Structural members Structure in molecular biology Thumb Tridimensional structure X-Ray Diffraction
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