Biochemical Characterization of a Novel Channel-Activating Site on Nicotinic Acetylcholine Receptors

Abstract We have studied the interaction of the reversible acetylcholine esterase inhibitor (-)physostigmine and several structurally related compounds with the nicotinic acetylcholine receptor (nAChR) from Torpedo marmorata electric tissue by means of ligand-induced ion flux into nAChR-rich membran...

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Veröffentlicht in:	Journal of receptor research 1993, Vol.13 (1-4), p.393-412
Hauptverfasser:	Schrattenholz, Andre, Coban, Thomas, Schröder, Bernd, Okonjo, Kehinde O., Kuhlmann, Jürgen, Pereira, Edna F., Albuquerque, Edson X., Maelicke, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology In Vitro Techniques Ion Channels - drug effects Molecular and cellular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Physostigmine - metabolism Physostigmine - pharmacology Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Torpedo
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