2,3-Butanedione monoxime (BDM) increases initial yields and improves long-term survival of isolated cardiac myocytes

2,3-Butanedione monoxime (BDM) increases initial yields and improves long-term survival of isolated cardiac myocytes

When BDM is added to the perfusion solutions used during the preparation of single, enzymatically dispersed mammalian cardiomyocytes, higher yields of calcium-tolerant cells are obtained. As the principal component of a storage solution, BDM also improves the survival of myocytes maintained in cold...

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Veröffentlicht in:Japanese journal of physiology 1995, Vol.45 (1), p.203
Hauptverfasser: Kivistö, T, Mäkiranta, M, Oikarinen, E L, Karhu, S, Weckström, M, Sellin, L C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Separation
Cell Survival - drug effects
Diacetyl - analogs & derivatives
Diacetyl - pharmacology
Heart - drug effects
Myocardium - cytology
Rats
Rats, Wistar
Time Factors
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Zusammenfassung:When BDM is added to the perfusion solutions used during the preparation of single, enzymatically dispersed mammalian cardiomyocytes, higher yields of calcium-tolerant cells are obtained. As the principal component of a storage solution, BDM also improves the survival of myocytes maintained in cold storage. These data support the hypothesis that BDM can act as a cardioprotective agent under certain conditions.
ISSN:0021-521X
DOI:10.2170/jjphysiol.45.203