Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer
To compare the healing rates of acute duodenal ulcer in patients receiving pantoprazole 40 mg or omeprazole 20 mg once daily and to assess drug tolerance. Randomized, double-blind study evaluating patients with healed duodenal ulcer on endoscopy after 2 weeks of treatment and patients unhealed at 2...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 1995-05, Vol.7 (5), p.407-410 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | BEKER, J. A BIANCHI PORRO, G BIGARD, M.-A DELLE FAVE, G DEVIS, G GOUEROU, H MAIER, C |
| description | To compare the healing rates of acute duodenal ulcer in patients receiving pantoprazole 40 mg or omeprazole 20 mg once daily and to assess drug tolerance.
Randomized, double-blind study evaluating patients with healed duodenal ulcer on endoscopy after 2 weeks of treatment and patients unhealed at 2 and after 4 weeks of treatment.
Hospital or private gastroenterology practice outpatients.
Men or women, aged at least 18 years, with one or two duodenal ulcers. Patients with ulcer complications or with other significant acid-related disease were excluded. A total of 270 patients entered the study, of whom 255 were included in the per-protocol analysis.
The primary measure of efficacy was the healing rates of duodenal ulcers. Complete healing of ulcers was observed in 88 (71%) of the 124 patients in the pantoprazole group and in 85 (65%) of the 131 patients in the omeprazole group after 2 weeks of treatment. The cumulative healing rates after 4 weeks were 118 (95%) out of 124 and 117 (89%) out of 131 patients, respectively. There was no significant difference between treatment groups with respect to either healing rates or freedom from ulcer pain at 2 weeks. Both treatments were well tolerated: only 10 and 11 patients in the pantoprazole and omeprazole groups, respectively, reported adverse events. Diarrhoea was reported by two patients in each group.
Pantoprazole 40 mg daily and omeprazole 20 mg daily are equally effective in inducing ulcer healing. |
| format | Article |
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Randomized, double-blind study evaluating patients with healed duodenal ulcer on endoscopy after 2 weeks of treatment and patients unhealed at 2 and after 4 weeks of treatment.
Hospital or private gastroenterology practice outpatients.
Men or women, aged at least 18 years, with one or two duodenal ulcers. Patients with ulcer complications or with other significant acid-related disease were excluded. A total of 270 patients entered the study, of whom 255 were included in the per-protocol analysis.
The primary measure of efficacy was the healing rates of duodenal ulcers. Complete healing of ulcers was observed in 88 (71%) of the 124 patients in the pantoprazole group and in 85 (65%) of the 131 patients in the omeprazole group after 2 weeks of treatment. The cumulative healing rates after 4 weeks were 118 (95%) out of 124 and 117 (89%) out of 131 patients, respectively. There was no significant difference between treatment groups with respect to either healing rates or freedom from ulcer pain at 2 weeks. Both treatments were well tolerated: only 10 and 11 patients in the pantoprazole and omeprazole groups, respectively, reported adverse events. Diarrhoea was reported by two patients in each group.
Pantoprazole 40 mg daily and omeprazole 20 mg daily are equally effective in inducing ulcer healing.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>PMID: 7614102</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles ; Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Ulcer Agents - administration & dosage ; Anti-Ulcer Agents - adverse effects ; Anti-Ulcer Agents - therapeutic use ; Benzimidazoles - administration & dosage ; Benzimidazoles - adverse effects ; Benzimidazoles - therapeutic use ; Biological and medical sciences ; Diarrhea - chemically induced ; Digestive system ; Double-Blind Method ; Drug Tolerance ; Duodenal Ulcer - drug therapy ; Duodenoscopy ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Omeprazole - administration & dosage ; Omeprazole - adverse effects ; Omeprazole - therapeutic use ; Pharmacology. Drug treatments ; Sulfoxides - administration & dosage ; Sulfoxides - adverse effects ; Sulfoxides - therapeutic use ; Wound Healing</subject><ispartof>European journal of gastroenterology & hepatology, 1995-05, Vol.7 (5), p.407-410</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3675482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7614102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BEKER, J. A</creatorcontrib><creatorcontrib>BIANCHI PORRO, G</creatorcontrib><creatorcontrib>BIGARD, M.-A</creatorcontrib><creatorcontrib>DELLE FAVE, G</creatorcontrib><creatorcontrib>DEVIS, G</creatorcontrib><creatorcontrib>GOUEROU, H</creatorcontrib><creatorcontrib>MAIER, C</creatorcontrib><title>Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>To compare the healing rates of acute duodenal ulcer in patients receiving pantoprazole 40 mg or omeprazole 20 mg once daily and to assess drug tolerance.
Randomized, double-blind study evaluating patients with healed duodenal ulcer on endoscopy after 2 weeks of treatment and patients unhealed at 2 and after 4 weeks of treatment.
Hospital or private gastroenterology practice outpatients.
Men or women, aged at least 18 years, with one or two duodenal ulcers. Patients with ulcer complications or with other significant acid-related disease were excluded. A total of 270 patients entered the study, of whom 255 were included in the per-protocol analysis.
The primary measure of efficacy was the healing rates of duodenal ulcers. Complete healing of ulcers was observed in 88 (71%) of the 124 patients in the pantoprazole group and in 85 (65%) of the 131 patients in the omeprazole group after 2 weeks of treatment. The cumulative healing rates after 4 weeks were 118 (95%) out of 124 and 117 (89%) out of 131 patients, respectively. There was no significant difference between treatment groups with respect to either healing rates or freedom from ulcer pain at 2 weeks. Both treatments were well tolerated: only 10 and 11 patients in the pantoprazole and omeprazole groups, respectively, reported adverse events. Diarrhoea was reported by two patients in each group.
Pantoprazole 40 mg daily and omeprazole 20 mg daily are equally effective in inducing ulcer healing.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles</subject><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Ulcer Agents - administration & dosage</subject><subject>Anti-Ulcer Agents - adverse effects</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Benzimidazoles - administration & dosage</subject><subject>Benzimidazoles - adverse effects</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diarrhea - chemically induced</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Drug Tolerance</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Duodenoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Omeprazole - administration & dosage</subject><subject>Omeprazole - adverse effects</subject><subject>Omeprazole - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Sulfoxides - administration & dosage</subject><subject>Sulfoxides - adverse effects</subject><subject>Sulfoxides - therapeutic use</subject><subject>Wound Healing</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01LxDAQhoMo67r6E4QcvBbyneYo6ycseFHwtk6TKVbSpqTpQX-9FVdPw_C87_DMEVlzZWWlTW2PyZo5rSrj-OspOZumD8a4ldyuyMoarjgTa_J2k-YmYtXEbgjUp36E3E1poKmlIwwljRm-UkQKC049_q1tyrS8Iy0ZofQ4lJ8C-LkgDXMKOECkc_SYz8lJC3HCi8PckJe72-ftQ7V7un_cXu-qUUhdFmGrsKnF4seC0UpzX3spkHkhDHrlTbAuMKmkY651FoFJGVA7y7lyTMsNufy9O85Nj2E_5q6H_Lk_fLrwqwOHyUNsMwy-m_5j0litaiG_AWQFXXM</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>BEKER, J. A</creator><creator>BIANCHI PORRO, G</creator><creator>BIGARD, M.-A</creator><creator>DELLE FAVE, G</creator><creator>DEVIS, G</creator><creator>GOUEROU, H</creator><creator>MAIER, C</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19950501</creationdate><title>Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer</title><author>BEKER, J. A ; BIANCHI PORRO, G ; BIGARD, M.-A ; DELLE FAVE, G ; DEVIS, G ; GOUEROU, H ; MAIER, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-5674eb827310d65451c8c32e0c226ec4c6d79d0343909f97ea033de5971149053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles</topic><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Ulcer Agents - administration & dosage</topic><topic>Anti-Ulcer Agents - adverse effects</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Benzimidazoles - administration & dosage</topic><topic>Benzimidazoles - adverse effects</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Diarrhea - chemically induced</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Drug Tolerance</topic><topic>Duodenal Ulcer - drug therapy</topic><topic>Duodenoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Omeprazole - administration & dosage</topic><topic>Omeprazole - adverse effects</topic><topic>Omeprazole - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Sulfoxides - administration & dosage</topic><topic>Sulfoxides - adverse effects</topic><topic>Sulfoxides - therapeutic use</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BEKER, J. A</creatorcontrib><creatorcontrib>BIANCHI PORRO, G</creatorcontrib><creatorcontrib>BIGARD, M.-A</creatorcontrib><creatorcontrib>DELLE FAVE, G</creatorcontrib><creatorcontrib>DEVIS, G</creatorcontrib><creatorcontrib>GOUEROU, H</creatorcontrib><creatorcontrib>MAIER, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEKER, J. A</au><au>BIANCHI PORRO, G</au><au>BIGARD, M.-A</au><au>DELLE FAVE, G</au><au>DEVIS, G</au><au>GOUEROU, H</au><au>MAIER, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>7</volume><issue>5</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>To compare the healing rates of acute duodenal ulcer in patients receiving pantoprazole 40 mg or omeprazole 20 mg once daily and to assess drug tolerance.
Randomized, double-blind study evaluating patients with healed duodenal ulcer on endoscopy after 2 weeks of treatment and patients unhealed at 2 and after 4 weeks of treatment.
Hospital or private gastroenterology practice outpatients.
Men or women, aged at least 18 years, with one or two duodenal ulcers. Patients with ulcer complications or with other significant acid-related disease were excluded. A total of 270 patients entered the study, of whom 255 were included in the per-protocol analysis.
The primary measure of efficacy was the healing rates of duodenal ulcers. Complete healing of ulcers was observed in 88 (71%) of the 124 patients in the pantoprazole group and in 85 (65%) of the 131 patients in the omeprazole group after 2 weeks of treatment. The cumulative healing rates after 4 weeks were 118 (95%) out of 124 and 117 (89%) out of 131 patients, respectively. There was no significant difference between treatment groups with respect to either healing rates or freedom from ulcer pain at 2 weeks. Both treatments were well tolerated: only 10 and 11 patients in the pantoprazole and omeprazole groups, respectively, reported adverse events. Diarrhoea was reported by two patients in each group.
Pantoprazole 40 mg daily and omeprazole 20 mg daily are equally effective in inducing ulcer healing.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7614102</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 1995-05, Vol.7 (5), p.407-410 |
| issn | 0954-691X 1473-5687 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles Acute Disease Adolescent Adult Aged Aged, 80 and over Anti-Ulcer Agents - administration & dosage Anti-Ulcer Agents - adverse effects Anti-Ulcer Agents - therapeutic use Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Benzimidazoles - therapeutic use Biological and medical sciences Diarrhea - chemically induced Digestive system Double-Blind Method Drug Tolerance Duodenal Ulcer - drug therapy Duodenoscopy Female Humans Male Medical sciences Middle Aged Omeprazole - administration & dosage Omeprazole - adverse effects Omeprazole - therapeutic use Pharmacology. Drug treatments Sulfoxides - administration & dosage Sulfoxides - adverse effects Sulfoxides - therapeutic use Wound Healing |
| title | Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer |
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