Effects of natural polyphenols on aflatoxin B1 activation in a reconstituted microsomal monooxygenase system

Covalent adduct formation between aflatoxin B1 and DNA, as catalyzed by a reconstituted microsomal monooxygenase system containing purified cytochrome P450 and NADPH-cytochrome P450 reductase, was observed to be inhibited by certain polyphenolic compounds of natural origin. Polyhydroxylated flavonoi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biochemical toxicology 1995-02, Vol.10 (1), p.25
Hauptverfasser:	Firozi, P F, Bhattacharya, R K
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6-Dichloroindophenol - metabolism Aflatoxin B1 - metabolism Animals Biotransformation - drug effects Cytochrome c Group - metabolism Cytochrome P-450 Enzyme System - metabolism DNA Adducts - metabolism Flavonoids - pharmacology Male Microsomes, Liver - metabolism NADH Dehydrogenase - physiology NADPH-Ferrihemoprotein Reductase Oxidoreductases - antagonists & inhibitors Phenols - metabolism Phenols - pharmacology Phosphatidylcholines - metabolism Polymers - metabolism Polymers - pharmacology Rats Rats, Wistar
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!