Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig
1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig. 2. Indocyanine green plasma and...
Gespeichert in:
| Veröffentlicht in: | Xenobiotica 1995, Vol.25 (5), p.491-499 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 499 |
|---|---|
| container_issue | 5 |
| container_start_page | 491 |
| container_title | Xenobiotica |
| container_volume | 25 |
| creator | Monshouwer, M. Witkamp, R. F. Nijmeijer, S. M. Pijpers, A. Verheijden, J. H. M. Van Miert, A. S. J. P. A. M. |
| description | 1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig.
2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected.
3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%.
4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation. |
| doi_str_mv | 10.3109/00498259509061868 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_7571722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77604723</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-447d8959212dacd193ea23c0e65dcef9207e631dd327949112776dd3d78371713</originalsourceid><addsrcrecordid>eNp9kUuLFDEQxxtR1nH1A3gQchBRsDWPfoX1siy-YMGDem5qk-qdLOmkTbqV-VB-R6tnxgUR9lSV-v-qKlVVFE8Ff6ME1285r3Qna11zzRvRNd29YiNU05S1lt39YrPqJQHVw-JRzjecEyXlSXHS1q1opdwUv7-iRzO7n8hwGMjLLA4M2BWYGZMDz1xYwy4G9vKcbIgkOe-XzCaPS4pTwGWMwQG-YgTNW2RbnGB2hhmPkCAY3Bc1QA1cwNcMwuymXdr7ExEGZxijXwVL_Ww0OwiksuuEGCiyrzq568fFgwF8xidHe1p8__D-28Wn8vLLx88X55elqRSfy6pqbadpB0JaMFZohSCV4djU1uCgJW-xUcJaJVtdaSFk2zb0sm2naC9CnRYvDnWnFH8smOd-dNmg9xAwLrknnFetVASKA2hSzDnh0E_JjZB2veD9eqL-vxNRzrNj8eVqRHubcbwJ6c-POmQDflg36PItpgijiQh7d8DoQDGN8Csmb_sZdj6mvznqrl-c_ZO-RfDz1kDC_iYuKdB675jhD_AMwGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77604723</pqid></control><display><type>article</type><title>Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Monshouwer, M. ; Witkamp, R. F. ; Nijmeijer, S. M. ; Pijpers, A. ; Verheijden, J. H. M. ; Van Miert, A. S. J. P. A. M.</creator><creatorcontrib>Monshouwer, M. ; Witkamp, R. F. ; Nijmeijer, S. M. ; Pijpers, A. ; Verheijden, J. H. M. ; Van Miert, A. S. J. P. A. M.</creatorcontrib><description>1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig.
2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected.
3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%.
4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation.</description><identifier>ISSN: 0049-8254</identifier><identifier>EISSN: 1366-5928</identifier><identifier>DOI: 10.3109/00498259509061868</identifier><identifier>PMID: 7571722</identifier><identifier>CODEN: XENOBH</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Acetaminophen - pharmacokinetics ; Actinobacillus Infections - metabolism ; Actinobacillus pleuropneumoniae ; Animals ; Antipyrine - analogs & derivatives ; Antipyrine - pharmacokinetics ; Biological and medical sciences ; Caffeine - pharmacokinetics ; Creatinine - blood ; Creatinine - urine ; General pharmacology ; Indocyanine Green - pharmacokinetics ; Liver - metabolism ; Male ; Medical sciences ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Swine</subject><ispartof>Xenobiotica, 1995, Vol.25 (5), p.491-499</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-447d8959212dacd193ea23c0e65dcef9207e631dd327949112776dd3d78371713</citedby><cites>FETCH-LOGICAL-c430t-447d8959212dacd193ea23c0e65dcef9207e631dd327949112776dd3d78371713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00498259509061868$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00498259509061868$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3571193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7571722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monshouwer, M.</creatorcontrib><creatorcontrib>Witkamp, R. F.</creatorcontrib><creatorcontrib>Nijmeijer, S. M.</creatorcontrib><creatorcontrib>Pijpers, A.</creatorcontrib><creatorcontrib>Verheijden, J. H. M.</creatorcontrib><creatorcontrib>Van Miert, A. S. J. P. A. M.</creatorcontrib><title>Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig</title><title>Xenobiotica</title><addtitle>Xenobiotica</addtitle><description>1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig.
2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected.
3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%.
4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation.</description><subject>Acetaminophen - pharmacokinetics</subject><subject>Actinobacillus Infections - metabolism</subject><subject>Actinobacillus pleuropneumoniae</subject><subject>Animals</subject><subject>Antipyrine - analogs & derivatives</subject><subject>Antipyrine - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Caffeine - pharmacokinetics</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>General pharmacology</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Swine</subject><issn>0049-8254</issn><issn>1366-5928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEQxxtR1nH1A3gQchBRsDWPfoX1siy-YMGDem5qk-qdLOmkTbqV-VB-R6tnxgUR9lSV-v-qKlVVFE8Ff6ME1285r3Qna11zzRvRNd29YiNU05S1lt39YrPqJQHVw-JRzjecEyXlSXHS1q1opdwUv7-iRzO7n8hwGMjLLA4M2BWYGZMDz1xYwy4G9vKcbIgkOe-XzCaPS4pTwGWMwQG-YgTNW2RbnGB2hhmPkCAY3Bc1QA1cwNcMwuymXdr7ExEGZxijXwVL_Ww0OwiksuuEGCiyrzq568fFgwF8xidHe1p8__D-28Wn8vLLx88X55elqRSfy6pqbadpB0JaMFZohSCV4djU1uCgJW-xUcJaJVtdaSFk2zb0sm2naC9CnRYvDnWnFH8smOd-dNmg9xAwLrknnFetVASKA2hSzDnh0E_JjZB2veD9eqL-vxNRzrNj8eVqRHubcbwJ6c-POmQDflg36PItpgijiQh7d8DoQDGN8Csmb_sZdj6mvznqrl-c_ZO-RfDz1kDC_iYuKdB675jhD_AMwGg</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Monshouwer, M.</creator><creator>Witkamp, R. F.</creator><creator>Nijmeijer, S. M.</creator><creator>Pijpers, A.</creator><creator>Verheijden, J. H. M.</creator><creator>Van Miert, A. S. J. P. A. M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig</title><author>Monshouwer, M. ; Witkamp, R. F. ; Nijmeijer, S. M. ; Pijpers, A. ; Verheijden, J. H. M. ; Van Miert, A. S. J. P. A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-447d8959212dacd193ea23c0e65dcef9207e631dd327949112776dd3d78371713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acetaminophen - pharmacokinetics</topic><topic>Actinobacillus Infections - metabolism</topic><topic>Actinobacillus pleuropneumoniae</topic><topic>Animals</topic><topic>Antipyrine - analogs & derivatives</topic><topic>Antipyrine - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Caffeine - pharmacokinetics</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>General pharmacology</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monshouwer, M.</creatorcontrib><creatorcontrib>Witkamp, R. F.</creatorcontrib><creatorcontrib>Nijmeijer, S. M.</creatorcontrib><creatorcontrib>Pijpers, A.</creatorcontrib><creatorcontrib>Verheijden, J. H. M.</creatorcontrib><creatorcontrib>Van Miert, A. S. J. P. A. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Xenobiotica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monshouwer, M.</au><au>Witkamp, R. F.</au><au>Nijmeijer, S. M.</au><au>Pijpers, A.</au><au>Verheijden, J. H. M.</au><au>Van Miert, A. S. J. P. A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig</atitle><jtitle>Xenobiotica</jtitle><addtitle>Xenobiotica</addtitle><date>1995</date><risdate>1995</risdate><volume>25</volume><issue>5</issue><spage>491</spage><epage>499</epage><pages>491-499</pages><issn>0049-8254</issn><eissn>1366-5928</eissn><coden>XENOBH</coden><abstract>1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig.
2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected.
3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%.
4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>7571722</pmid><doi>10.3109/00498259509061868</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-8254 |
| ispartof | Xenobiotica, 1995, Vol.25 (5), p.491-499 |
| issn | 0049-8254 1366-5928 |
| language | eng |
| recordid | cdi_pubmed_primary_7571722 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Acetaminophen - pharmacokinetics Actinobacillus Infections - metabolism Actinobacillus pleuropneumoniae Animals Antipyrine - analogs & derivatives Antipyrine - pharmacokinetics Biological and medical sciences Caffeine - pharmacokinetics Creatinine - blood Creatinine - urine General pharmacology Indocyanine Green - pharmacokinetics Liver - metabolism Male Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Swine |
| title | Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T20%3A43%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selective%20effects%20of%20a%20bacterial%20infection%20(Actinobacillus%20pleuropneumoniae)%20on%20the%20hepatic%20clearances%20of%20caffeine,%20antipyrine,%20paracetamol,%20and%20indocyanine%20green%20in%20the%20pig&rft.jtitle=Xenobiotica&rft.au=Monshouwer,%20M.&rft.date=1995&rft.volume=25&rft.issue=5&rft.spage=491&rft.epage=499&rft.pages=491-499&rft.issn=0049-8254&rft.eissn=1366-5928&rft.coden=XENOBH&rft_id=info:doi/10.3109/00498259509061868&rft_dat=%3Cproquest_pubme%3E77604723%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77604723&rft_id=info:pmid/7571722&rfr_iscdi=true |