Acute Toxicity of Tetramethylbenzenes: Durene, Isodurene and Prehnitene
ABSTRACT Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene, isodurene and prehnitene. The order of oral toxicity was isodurene > prehnitene > durene. Durene...
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| Veröffentlicht in: | Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 1978, Vol.1 (3), p.219-230 |
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| container_issue | 3 |
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| container_title | Drug and chemical toxicology (New York, N.Y. 1978) |
| container_volume | 1 |
| creator | Lynch, Dennis W. Perone, Vernon B. Schuler, Ronald L. Ushry, William B. Lewis, Trent R. |
| description | ABSTRACT
Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene, isodurene and prehnitene. The order of oral toxicity was isodurene > prehnitene > durene. Durene was not a skin irritant, while isodurene and prehnitene each produced a mild positive skin response (erythema). None of the tetramethylbenzenes were skin sensitizers or eye irritants. Durene, isodurene and prehnitene are only slightly toxic on an acute toxicologic basis and only pose an acute health hazard when injested in excessive quantities. |
| doi_str_mv | 10.3109/01480547809105016 |
| format | Article |
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Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene, isodurene and prehnitene. The order of oral toxicity was isodurene > prehnitene > durene. Durene was not a skin irritant, while isodurene and prehnitene each produced a mild positive skin response (erythema). None of the tetramethylbenzenes were skin sensitizers or eye irritants. Durene, isodurene and prehnitene are only slightly toxic on an acute toxicologic basis and only pose an acute health hazard when injested in excessive quantities.</description><identifier>ISSN: 0148-0545</identifier><identifier>EISSN: 1525-6014</identifier><identifier>DOI: 10.3109/01480547809105016</identifier><identifier>PMID: 755669</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Animals ; Benzene Derivatives - toxicity ; Eye - drug effects ; Guinea Pigs ; Irritants ; Lethal Dose 50 ; Male ; Rabbits ; Rats ; Skin - drug effects</subject><ispartof>Drug and chemical toxicology (New York, N.Y. 1978), 1978, Vol.1 (3), p.219-230</ispartof><rights>1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-53c41883974a946324f228a51af12f87c4efd5d42226b8cac2db72733cb7cff23</citedby><cites>FETCH-LOGICAL-c400t-53c41883974a946324f228a51af12f87c4efd5d42226b8cac2db72733cb7cff23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/01480547809105016$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/01480547809105016$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/755669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, Dennis W.</creatorcontrib><creatorcontrib>Perone, Vernon B.</creatorcontrib><creatorcontrib>Schuler, Ronald L.</creatorcontrib><creatorcontrib>Ushry, William B.</creatorcontrib><creatorcontrib>Lewis, Trent R.</creatorcontrib><title>Acute Toxicity of Tetramethylbenzenes: Durene, Isodurene and Prehnitene</title><title>Drug and chemical toxicology (New York, N.Y. 1978)</title><addtitle>Drug Chem Toxicol</addtitle><description>ABSTRACT
Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene, isodurene and prehnitene. The order of oral toxicity was isodurene > prehnitene > durene. Durene was not a skin irritant, while isodurene and prehnitene each produced a mild positive skin response (erythema). None of the tetramethylbenzenes were skin sensitizers or eye irritants. Durene, isodurene and prehnitene are only slightly toxic on an acute toxicologic basis and only pose an acute health hazard when injested in excessive quantities.</description><subject>Animals</subject><subject>Benzene Derivatives - toxicity</subject><subject>Eye - drug effects</subject><subject>Guinea Pigs</subject><subject>Irritants</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Skin - drug effects</subject><issn>0148-0545</issn><issn>1525-6014</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYP4Gkd_gOCiP8Bqnn2om2F8DQzoYlyXNE1ohzYZkhStv96MFUFEV_dczj2HywfAKYIXBMH8EiKaQUbTDOYIMoiSHTBBDLM4Cc4umGz9OBywQ3Dk3BpChHNGDsB-yliS5BPwMBO9l9HKvDWi8UNkVLSS3vJO-npoS6nfpZbuKrrtbRDn0cKZ6lNGXFfRs5W1bnxYj8Ge4q2TJ19zCl7u71bzx3j59LCYz5axoBD6mBFBUZaRPKU8pwnBVGGccYa4QlhlqaBSVayiGOOkzAQXuCpTnBIiylQohckUoLFXWOOclarY2KbjdigQLLZIil9IQuZszGz6spPVd2JkEOyb0W60Mrbjr8a2VeH50BqrLNeicdvmv9uvf8RryVtfC25lsTa91YHGP799AOdGgL8</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>Lynch, Dennis W.</creator><creator>Perone, Vernon B.</creator><creator>Schuler, Ronald L.</creator><creator>Ushry, William B.</creator><creator>Lewis, Trent R.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1978</creationdate><title>Acute Toxicity of Tetramethylbenzenes: Durene, Isodurene and Prehnitene</title><author>Lynch, Dennis W. ; Perone, Vernon B. ; Schuler, Ronald L. ; Ushry, William B. ; Lewis, Trent R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-53c41883974a946324f228a51af12f87c4efd5d42226b8cac2db72733cb7cff23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Benzene Derivatives - toxicity</topic><topic>Eye - drug effects</topic><topic>Guinea Pigs</topic><topic>Irritants</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Skin - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, Dennis W.</creatorcontrib><creatorcontrib>Perone, Vernon B.</creatorcontrib><creatorcontrib>Schuler, Ronald L.</creatorcontrib><creatorcontrib>Ushry, William B.</creatorcontrib><creatorcontrib>Lewis, Trent R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, Dennis W.</au><au>Perone, Vernon B.</au><au>Schuler, Ronald L.</au><au>Ushry, William B.</au><au>Lewis, Trent R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Toxicity of Tetramethylbenzenes: Durene, Isodurene and Prehnitene</atitle><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle><addtitle>Drug Chem Toxicol</addtitle><date>1978</date><risdate>1978</risdate><volume>1</volume><issue>3</issue><spage>219</spage><epage>230</epage><pages>219-230</pages><issn>0148-0545</issn><eissn>1525-6014</eissn><abstract>ABSTRACT
Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene, isodurene and prehnitene. The order of oral toxicity was isodurene > prehnitene > durene. Durene was not a skin irritant, while isodurene and prehnitene each produced a mild positive skin response (erythema). None of the tetramethylbenzenes were skin sensitizers or eye irritants. Durene, isodurene and prehnitene are only slightly toxic on an acute toxicologic basis and only pose an acute health hazard when injested in excessive quantities.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>755669</pmid><doi>10.3109/01480547809105016</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-0545 |
| ispartof | Drug and chemical toxicology (New York, N.Y. 1978), 1978, Vol.1 (3), p.219-230 |
| issn | 0148-0545 1525-6014 |
| language | eng |
| recordid | cdi_pubmed_primary_755669 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Benzene Derivatives - toxicity Eye - drug effects Guinea Pigs Irritants Lethal Dose 50 Male Rabbits Rats Skin - drug effects |
| title | Acute Toxicity of Tetramethylbenzenes: Durene, Isodurene and Prehnitene |
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