Inhibitors of free radical formation fail to attenuate direct β-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures

The direct neurotoxic action of the β‐amyloid protein, the major constituent of senile plaques, may represent the underlying cause of neuronal degeneration observed in Alzheimer's disease. The apoptotic‐mediated neuronal death induced by β‐amyloid appears to reside in its ability to form Ca>...

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