Paradoxical Fate and Biological Action of Peroxynitrite on Human Platelets

Peroxynitrite (ONOO-), which is formed from the reaction of nitric oxide (NO) and superoxide (O- 2), has been suggested to be responsible for some of the cytotoxic effects of these molecules. When protonated, ONOO-gives rise to hydroxyl (OH.) and nitrogen dioxide (NO2) radicals, which are capable of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-07, Vol.91 (14), p.6702-6706
Hauptverfasser:	Moro, Maria Angeles, Darley-Usmar, Victor M., Goodwin, David A., Read, Nicholas G., Zamora-Pino, Ruben, Feelisch, Martin, Radomski, Marek W., Moncada, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Antigens, CD - blood Blood plasma Blood Platelets - drug effects Blood Platelets - physiology Blood Platelets - ultrastructure Cell Adhesion Molecules - blood Cellular biology Collagen - pharmacology Collagens Epoprostenol - pharmacology Glutathione - analogs & derivatives Glutathione - pharmacology Health savings accounts Hemoglobins Hemoglobins - pharmacology Humans In Vitro Techniques Indomethacin - pharmacology Kinetics Nitrates - blood Nitrates - pharmacology Nitroso Compounds - pharmacology Oxidation P-Selectin Penicillamine - analogs & derivatives Penicillamine - pharmacology Pharmacology Phosphates Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Membrane Glycoproteins - blood Platelets S-Nitroso-N-Acetylpenicillamine S-Nitrosoglutathione Serum Albumin - pharmacology Sodium Thiols Time Factors Vasodilator Agents - pharmacology
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