Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets

Pancreatic islet transplantation may be the most ideal treatment for patients with insulin-dependent diabetes mellitus. However, immunosuppressive agents such as cyclosporine A(CsA) and FK506, used for these transplanted patients have been reported to cause glucose intolerance. In the present study,...

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Veröffentlicht in:	Transplantation 1993-12, Vol.56 (6), p.1486-1490
Hauptverfasser:	ISHIZUKA, J, GUGLIUZZA, K. K, WASSMUTH, Z, HSIEH, J, SATO, K, TSUCHIYA, T, TOWNSEND, C. M, FISH, J. C, THOMPSON, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclosporine - toxicity Dogs Drug toxicity and drugs side effects treatment Glucose - pharmacology Immunosuppression - adverse effects In Vitro Techniques Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans Transplantation - adverse effects Islets of Langerhans Transplantation - immunology Islets of Langerhans Transplantation - physiology Medical sciences Pharmacology. Drug treatments Tacrolimus - toxicity Toxicity: digestive system
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