Identification of a Hexapeptide that Mimics a Conformation-Dependent Binding Site of Acetylcholine Receptor by use of a Phage-Epitope Library

Monoclonal antibody (mAb) 5.5 is directed against the ligand-binding site of the nicotinic acetylcholine receptor. The epitope for this antibody is conformation-dependent, and the antibody does not react with synthetic peptides derived from the receptor sequence. We have identified a ligand peptide...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-11, Vol.90 (22), p.10638-10642
Hauptverfasser:	Balass, Moshe, Heldman, Yehudit, Cabilly, Shmuel, Givol, David, Katchalski-Katzir, Ephraim, Fuchs, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Antibodies Antibodies, Monoclonal - immunology Bacteriophages Binding Sites Binding, Competitive Biochemistry Biological and medical sciences Cell receptors Cell structures and functions Chickens Cloning, Molecular Epitopes Fundamental and applied biological sciences. Psychology Gene Library Genetic Vectors Immunization, Passive Inhibitory concentration 50 Inovirus - genetics Libraries Ligands Molecular and cellular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Neuromuscular blockade Oligopeptides - chemistry Oligopeptides - immunology Protein Conformation Receptors Receptors, Nicotinic - immunology
Online-Zugang:	Volltext
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