Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors

Ras CAAX (C = cysteine, A = aliphatic amino acid, and X = any amino acid) peptidomimetic inhibitors of farnesyl protein transferase suppress Ras-dependent cell transformation by preventing farnesylation of the Ras oncoprotein. These compounds are potential anticancer agents for tumors associated wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-11, Vol.92 (24), p.10919-10923
Hauptverfasser:	Kauffmann, R.C. (University of Pittsburgh, Pittsburgh, PA.), Qian, Y, Vogt, A, Sebti, S.M, Hamilton, A.D, Carthew, R.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases Amino Acid Sequence Amino acids Animals Cell lines DIFERENCIACION CELULAR DIFFERENCIATION CELLULAIRE Drosophila DROSOPHILA MELANOGASTER Drosophila melanogaster - anatomy & histology Enzyme Inhibitors - pharmacology Eye Abnormalities - etiology Farnesyltranstransferase INHIBICION INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME INHIBITION Insect larvae Larvae LARVAS LARVE Molecular Sequence Data NUCLEOTIDE NUCLEOTIDOS OEIL OJOS Oligopeptides - pharmacology Ommatidia ORGANE DES SENS ORGANOS SENSORIALES Peptidomimetics Phenotypes Photoreceptors PROTEINAS AGLUTINANTES PROTEINE DE LIAISON Proteins Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors Proto-Oncogene Proteins p21(ras) - physiology Signal Transduction TRANSFERASAS TRANSFERASE Transferases - antagonists & inhibitors Transferases - physiology
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