CARCINOEMBRYONIC ANTIGEN IN LIVER DISEASES: Elevated CEA levels and liver diseases with alcohol abuse
The measurement of carcinoembryonic antigen (CEA) by radioimmunoassay was carried out in various liver diseases, particularly associated with alcohol abuse (ethanol 150ml/day). On one hand, in 29 patients with liver diseases with alcohol abuse, 13 cases (45%) showed a positive CEA titer in sera (20n...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1980/10/05, Vol.77(10), pp.1575-1580 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
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| creator | YAMAGUCHI, Nozomi KIMOTO, Kunihiko MACHINO, Mitsuo TAKEUCHI, Satoru UOZUMI, Gentsu TANAKA, Yoshinori AOIKE, Akira KAWAI, Keiichi |
| description | The measurement of carcinoembryonic antigen (CEA) by radioimmunoassay was carried out in various liver diseases, particularly associated with alcohol abuse (ethanol 150ml/day). On one hand, in 29 patients with liver diseases with alcohol abuse, 13 cases (45%) showed a positive CEA titer in sera (20ng/ml), on the other hand, in 74 patients with liver diseases without alcohol abuse, only 11 cases (15%) showed a positive CEA titer. It is obvious that in liver diseases with alcohol abuse may significantly cause the elevation of serum CEA level. Using the antiserum originally prepared at our laboratory, we studied the localization of CEA in biopsied liver specimens by immuno-peroxidase method (PAP). This means that hyperproduction of CEA in reconstructed liver cells of liver diseases with alcohol abuse may cause the high percentage of positive CEA in liver diseases with alcohol abuse. Then, the elvation of CEA level in liver diseases caused by the decreased CEA catabolism is one of the mechanisms of high percentage of positive CEA in liver diseases with alcohol abuse. We suppose that some parts of the liver cell function disturbed by alcohol abuse may be overlaped with the liver function of CEA catabolism. |
| doi_str_mv | 10.11405/nisshoshi1964.77.10_1575 |
| format | Article |
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On one hand, in 29 patients with liver diseases with alcohol abuse, 13 cases (45%) showed a positive CEA titer in sera (20ng/ml), on the other hand, in 74 patients with liver diseases without alcohol abuse, only 11 cases (15%) showed a positive CEA titer. It is obvious that in liver diseases with alcohol abuse may significantly cause the elevation of serum CEA level. Using the antiserum originally prepared at our laboratory, we studied the localization of CEA in biopsied liver specimens by immuno-peroxidase method (PAP). This means that hyperproduction of CEA in reconstructed liver cells of liver diseases with alcohol abuse may cause the high percentage of positive CEA in liver diseases with alcohol abuse. Then, the elvation of CEA level in liver diseases caused by the decreased CEA catabolism is one of the mechanisms of high percentage of positive CEA in liver diseases with alcohol abuse. We suppose that some parts of the liver cell function disturbed by alcohol abuse may be overlaped with the liver function of CEA catabolism.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.77.10_1575</identifier><identifier>PMID: 7452949</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>Carcinoembryonic antigen (CEA) ; Carcinoembryonic Antigen - analysis ; Humans ; Liver Cirrhosis, Alcoholic - immunology ; Liver Diseases - immunology ; Liver Diseases, Alcoholic - immunology ; Radioimmunoassay (RIA)</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1980/10/05, Vol.77(10), pp.1575-1580</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7452949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMAGUCHI, Nozomi</creatorcontrib><creatorcontrib>KIMOTO, Kunihiko</creatorcontrib><creatorcontrib>MACHINO, Mitsuo</creatorcontrib><creatorcontrib>TAKEUCHI, Satoru</creatorcontrib><creatorcontrib>UOZUMI, Gentsu</creatorcontrib><creatorcontrib>TANAKA, Yoshinori</creatorcontrib><creatorcontrib>AOIKE, Akira</creatorcontrib><creatorcontrib>KAWAI, Keiichi</creatorcontrib><title>CARCINOEMBRYONIC ANTIGEN IN LIVER DISEASES: Elevated CEA levels and liver diseases with alcohol abuse</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>The measurement of carcinoembryonic antigen (CEA) by radioimmunoassay was carried out in various liver diseases, particularly associated with alcohol abuse (ethanol 150ml/day). On one hand, in 29 patients with liver diseases with alcohol abuse, 13 cases (45%) showed a positive CEA titer in sera (20ng/ml), on the other hand, in 74 patients with liver diseases without alcohol abuse, only 11 cases (15%) showed a positive CEA titer. It is obvious that in liver diseases with alcohol abuse may significantly cause the elevation of serum CEA level. Using the antiserum originally prepared at our laboratory, we studied the localization of CEA in biopsied liver specimens by immuno-peroxidase method (PAP). This means that hyperproduction of CEA in reconstructed liver cells of liver diseases with alcohol abuse may cause the high percentage of positive CEA in liver diseases with alcohol abuse. Then, the elvation of CEA level in liver diseases caused by the decreased CEA catabolism is one of the mechanisms of high percentage of positive CEA in liver diseases with alcohol abuse. We suppose that some parts of the liver cell function disturbed by alcohol abuse may be overlaped with the liver function of CEA catabolism.</description><subject>Carcinoembryonic antigen (CEA)</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Humans</subject><subject>Liver Cirrhosis, Alcoholic - immunology</subject><subject>Liver Diseases - immunology</subject><subject>Liver Diseases, Alcoholic - immunology</subject><subject>Radioimmunoassay (RIA)</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AURQdRaqn9CULcCokzma-8ZYyxDsQE0iq4GiaZiU1pa8nUhf_eSkvBzbuLc7k8DkJ3BEeEMMwftr33yy-_7AkIFkkZEawJl_wCjQllEEoB9BKNMWMiFDwR12jqfd9gjIFDQukIjSTjMTAYo_ssrTNVVvnrY_1RlSoL0nKhZnkZqDIo1HteB09qnqfzfH6Drjqz9m56ygl6e84X2UtYVDOVpUW4InEMoQFBWtsx0wBYIZmkcedY0gjOwcoYO9465rg0ccssMR3lLUmMYcJZSzBYOkG3x93dd7NxVu-GfmOGH336-cCLI1_5vfl0Z26Gfd-unf6nR0upD3qO90_SudYuzaDdlv4Cr8leVg</recordid><startdate>198010</startdate><enddate>198010</enddate><creator>YAMAGUCHI, Nozomi</creator><creator>KIMOTO, Kunihiko</creator><creator>MACHINO, Mitsuo</creator><creator>TAKEUCHI, Satoru</creator><creator>UOZUMI, Gentsu</creator><creator>TANAKA, Yoshinori</creator><creator>AOIKE, Akira</creator><creator>KAWAI, Keiichi</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198010</creationdate><title>CARCINOEMBRYONIC ANTIGEN IN LIVER DISEASES</title><author>YAMAGUCHI, Nozomi ; KIMOTO, Kunihiko ; MACHINO, Mitsuo ; TAKEUCHI, Satoru ; UOZUMI, Gentsu ; TANAKA, Yoshinori ; AOIKE, Akira ; KAWAI, Keiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1229-a961cdf4ab99d674732fe48b6559d720e5ce4e57a2c4d1af35c18aa46edd109d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1980</creationdate><topic>Carcinoembryonic antigen (CEA)</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Humans</topic><topic>Liver Cirrhosis, Alcoholic - immunology</topic><topic>Liver Diseases - immunology</topic><topic>Liver Diseases, Alcoholic - immunology</topic><topic>Radioimmunoassay (RIA)</topic><toplevel>online_resources</toplevel><creatorcontrib>YAMAGUCHI, Nozomi</creatorcontrib><creatorcontrib>KIMOTO, Kunihiko</creatorcontrib><creatorcontrib>MACHINO, Mitsuo</creatorcontrib><creatorcontrib>TAKEUCHI, Satoru</creatorcontrib><creatorcontrib>UOZUMI, Gentsu</creatorcontrib><creatorcontrib>TANAKA, Yoshinori</creatorcontrib><creatorcontrib>AOIKE, Akira</creatorcontrib><creatorcontrib>KAWAI, Keiichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMAGUCHI, Nozomi</au><au>KIMOTO, Kunihiko</au><au>MACHINO, Mitsuo</au><au>TAKEUCHI, Satoru</au><au>UOZUMI, Gentsu</au><au>TANAKA, Yoshinori</au><au>AOIKE, Akira</au><au>KAWAI, Keiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CARCINOEMBRYONIC ANTIGEN IN LIVER DISEASES: Elevated CEA levels and liver diseases with alcohol abuse</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1980-10</date><risdate>1980</risdate><volume>77</volume><issue>10</issue><spage>1575</spage><epage>1580</epage><pages>1575-1580</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>The measurement of carcinoembryonic antigen (CEA) by radioimmunoassay was carried out in various liver diseases, particularly associated with alcohol abuse (ethanol 150ml/day). On one hand, in 29 patients with liver diseases with alcohol abuse, 13 cases (45%) showed a positive CEA titer in sera (20ng/ml), on the other hand, in 74 patients with liver diseases without alcohol abuse, only 11 cases (15%) showed a positive CEA titer. It is obvious that in liver diseases with alcohol abuse may significantly cause the elevation of serum CEA level. Using the antiserum originally prepared at our laboratory, we studied the localization of CEA in biopsied liver specimens by immuno-peroxidase method (PAP). This means that hyperproduction of CEA in reconstructed liver cells of liver diseases with alcohol abuse may cause the high percentage of positive CEA in liver diseases with alcohol abuse. Then, the elvation of CEA level in liver diseases caused by the decreased CEA catabolism is one of the mechanisms of high percentage of positive CEA in liver diseases with alcohol abuse. We suppose that some parts of the liver cell function disturbed by alcohol abuse may be overlaped with the liver function of CEA catabolism.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>7452949</pmid><doi>10.11405/nisshoshi1964.77.10_1575</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1980/10/05, Vol.77(10), pp.1575-1580 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
| recordid | cdi_pubmed_primary_7452949 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Carcinoembryonic antigen (CEA) Carcinoembryonic Antigen - analysis Humans Liver Cirrhosis, Alcoholic - immunology Liver Diseases - immunology Liver Diseases, Alcoholic - immunology Radioimmunoassay (RIA) |
| title | CARCINOEMBRYONIC ANTIGEN IN LIVER DISEASES: Elevated CEA levels and liver diseases with alcohol abuse |
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