Effect of dose, schedule, and route of administration on the in vivo toxicity and antitumor activity of two activated sulfhydryl derivatives of cyclophosphamide

Two cyclophosphamide (CP) derivatives, 4-S-(hexane-6-ol)-sulfidocyclophosphamide (C-1) and 4-S-(propionic acid)-sulfidocyclophosphamide (C-2), that hydrolyze spontaneously under physiological conditions to 4-hydroxycyclophosphamide, are compared to CP for antitumor activity in male C57BL/6 x DBA/2 F...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1980-10, Vol.40 (10), p.3704
Hauptverfasser:	Ramonas, L M, Erickson, L C, Ringsdorf, H, Zaharko, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Cyclophosphamide - analogs & derivatives Dose-Response Relationship, Drug Drug Administration Schedule Drug Evaluation, Preclinical Injections, Intraperitoneal Injections, Intravenous Leukemia L1210 - drug therapy Leukemia L1210 - pathology Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Mice Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology
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