Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity
Nuclei isolated from hamster liver contain activities characteristic of the mixed-function amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase, catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram protein of isolated nuclei is 12-14% that...
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| Veröffentlicht in: | Molecular pharmacology 1980-07, Vol.18 (1), p.151 |
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| creator | Patton, S E Rosen, G M Rauckman, E J Graham, D G Small, B Ziegler, D M |
| description | Nuclei isolated from hamster liver contain activities characteristic of the mixed-function
amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase,
catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram
protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase
cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal
mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase
is largely concentrated in the nuclear envelope. |
| format | Article |
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amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase,
catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram
protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase
cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal
mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase
is largely concentrated in the nuclear envelope.</description><identifier>ISSN: 0026-895X</identifier><identifier>EISSN: 1521-0111</identifier><identifier>PMID: 7412759</identifier><language>eng</language><publisher>United States: American Society for Pharmacology and Experimental Therapeutics</publisher><subject>Animals ; Cell Nucleus - enzymology ; Cricetinae ; Cytochrome P-450 Enzyme System - metabolism ; Liver - enzymology ; Liver - ultrastructure ; Male ; Mesocricetus ; Microsomes, Liver - enzymology ; Mixed Function Oxygenases - metabolism ; Oxidoreductases - metabolism ; Swine</subject><ispartof>Molecular pharmacology, 1980-07, Vol.18 (1), p.151</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7412759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patton, S E</creatorcontrib><creatorcontrib>Rosen, G M</creatorcontrib><creatorcontrib>Rauckman, E J</creatorcontrib><creatorcontrib>Graham, D G</creatorcontrib><creatorcontrib>Small, B</creatorcontrib><creatorcontrib>Ziegler, D M</creatorcontrib><title>Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity</title><title>Molecular pharmacology</title><addtitle>Mol Pharmacol</addtitle><description>Nuclei isolated from hamster liver contain activities characteristic of the mixed-function
amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase,
catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram
protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase
cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal
mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase
is largely concentrated in the nuclear envelope.</description><subject>Animals</subject><subject>Cell Nucleus - enzymology</subject><subject>Cricetinae</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Liver - enzymology</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Microsomes, Liver - enzymology</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Oxidoreductases - metabolism</subject><subject>Swine</subject><issn>0026-895X</issn><issn>1521-0111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj09Lw0AUxBdRaq1-BGEvHgP7krzuxlsp1grVHqzgLbxu3jYrzR-SVJtv32B7GpjfzMBciTFgCIECgGsxViqcBibB71tx17Y_SkGMRo3ESMcQakzGYrOkou24kUuuqfNWfhzsnqmR7_7IWbA4lLbzVSlnhS9Zro8-o5af5aqy9O9TmcnPmq13Q3c2ZH9919-LG0f7lh8uOhFfi5fNfBms1q9v89kqyEOFXYCJYgCGLNNoWG-dcWQJE5NM0bJF4xIVgZqiAtaoDUXDHYxdTBFqF22jiXg879aHbcFZWje-oKZPL-8G_nTmud_lf77htM6pKchW-2rXp2BSSAEhOgHegVj5</recordid><startdate>198007</startdate><enddate>198007</enddate><creator>Patton, S E</creator><creator>Rosen, G M</creator><creator>Rauckman, E J</creator><creator>Graham, D G</creator><creator>Small, B</creator><creator>Ziegler, D M</creator><general>American Society for Pharmacology and Experimental Therapeutics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198007</creationdate><title>Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity</title><author>Patton, S E ; Rosen, G M ; Rauckman, E J ; Graham, D G ; Small, B ; Ziegler, D M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h205t-590e11e1dd758e7bf8faca598965cec58f903106501e7578a302654f4a357f3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cell Nucleus - enzymology</topic><topic>Cricetinae</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Liver - enzymology</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Microsomes, Liver - enzymology</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Oxidoreductases - metabolism</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patton, S E</creatorcontrib><creatorcontrib>Rosen, G M</creatorcontrib><creatorcontrib>Rauckman, E J</creatorcontrib><creatorcontrib>Graham, D G</creatorcontrib><creatorcontrib>Small, B</creatorcontrib><creatorcontrib>Ziegler, D M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Molecular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patton, S E</au><au>Rosen, G M</au><au>Rauckman, E J</au><au>Graham, D G</au><au>Small, B</au><au>Ziegler, D M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity</atitle><jtitle>Molecular pharmacology</jtitle><addtitle>Mol Pharmacol</addtitle><date>1980-07</date><risdate>1980</risdate><volume>18</volume><issue>1</issue><spage>151</spage><pages>151-</pages><issn>0026-895X</issn><eissn>1521-0111</eissn><abstract>Nuclei isolated from hamster liver contain activities characteristic of the mixed-function
amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase,
catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram
protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase
cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal
mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase
is largely concentrated in the nuclear envelope.</abstract><cop>United States</cop><pub>American Society for Pharmacology and Experimental Therapeutics</pub><pmid>7412759</pmid></addata></record> |
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| ispartof | Molecular pharmacology, 1980-07, Vol.18 (1), p.151 |
| issn | 0026-895X 1521-0111 |
| language | eng |
| recordid | cdi_pubmed_primary_7412759 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Nucleus - enzymology Cricetinae Cytochrome P-450 Enzyme System - metabolism Liver - enzymology Liver - ultrastructure Male Mesocricetus Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Oxidoreductases - metabolism Swine |
| title | Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity |
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