Digoxin-quinidine interaction: Changes in canine tissue concentration from steady state with quinidine

Tissue concentrations of tritiated digoxin in the dog are altered by simultaneous administration of quinidine. Serum levels rise as tissue concentration decreases significantly in all tissue except brain tissue, where an increase of 51 percent is noted over that of the control digltalized state. The...

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Veröffentlicht in:	The American journal of cardiology 1980-01, Vol.45 (6), p.1196-1200
Hauptverfasser:	Doherty, James E., Straub, K.David, Murphy, Marvin L., Soyza, Neil De, Bissett, Joe K., Kane, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Digitalis Glycosides - toxicity Digoxin - blood Digoxin - metabolism Dogs Gallbladder - metabolism Heart - drug effects Kidney - metabolism Liver - metabolism Muscles - drug effects Quinidine - blood Quinidine - metabolism Spleen - metabolism
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