A Collection of Guinea Pig Sensitization Test Results - Grouped by Chemical Class
ABSTRACT Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related...
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| Veröffentlicht in: | Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 1981, Vol.4 (4), p.331-351 |
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| container_end_page | 351 |
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| container_issue | 4 |
| container_start_page | 331 |
| container_title | Drug and chemical toxicology (New York, N.Y. 1978) |
| container_volume | 4 |
| creator | Rao, K. S. Betso, J. E. Olson, K. J. |
| description | ABSTRACT
Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions should be made with caution due to variability of sample purity or differences in methodology. It is important to realize that every chemical which is positive in the guinea pig should not be construed as definitive evidence of human skin sensitization. |
| doi_str_mv | 10.3109/01480548109017825 |
| format | Article |
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Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions should be made with caution due to variability of sample purity or differences in methodology. It is important to realize that every chemical which is positive in the guinea pig should not be construed as definitive evidence of human skin sensitization.</description><identifier>ISSN: 0148-0545</identifier><identifier>EISSN: 1525-6014</identifier><identifier>DOI: 10.3109/01480548109017825</identifier><identifier>PMID: 7344910</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Allergens ; Animals ; Drug Evaluation, Preclinical - methods ; Guinea Pigs - immunology ; Male ; Skin Tests ; Structure-Activity Relationship</subject><ispartof>Drug and chemical toxicology (New York, N.Y. 1978), 1981, Vol.4 (4), p.331-351</ispartof><rights>1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-62174afb04e0f6101352a6a3794124334f012221260a82c5ac66941e9b1c2a283</citedby><cites>FETCH-LOGICAL-c498t-62174afb04e0f6101352a6a3794124334f012221260a82c5ac66941e9b1c2a283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/01480548109017825$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/01480548109017825$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,778,782,4012,27906,27907,27908,59628,59734,60417,60523,61202,61237,61383,61418</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7344910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, K. S.</creatorcontrib><creatorcontrib>Betso, J. E.</creatorcontrib><creatorcontrib>Olson, K. J.</creatorcontrib><title>A Collection of Guinea Pig Sensitization Test Results - Grouped by Chemical Class</title><title>Drug and chemical toxicology (New York, N.Y. 1978)</title><addtitle>Drug Chem Toxicol</addtitle><description>ABSTRACT
Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions should be made with caution due to variability of sample purity or differences in methodology. It is important to realize that every chemical which is positive in the guinea pig should not be construed as definitive evidence of human skin sensitization.</description><subject>Allergens</subject><subject>Animals</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Guinea Pigs - immunology</subject><subject>Male</subject><subject>Skin Tests</subject><subject>Structure-Activity Relationship</subject><issn>0148-0545</issn><issn>1525-6014</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9r20AUxJeQ4jpOPkAPgT3lpmT_S6K9GJG6BUOb1DmL5_UqXrPSursSwfn0XdemEEKT03vwmxmGQegTJdeckvKGUFEQKYr0E5oXTJ6gMZVMZiqRUzTe8ywJ5Ed0FuOGEMpKyUdolHMhSkrG6G6KK--c0b31HfYNng22M4B_2kf8y3TR9vYZ_rKFiT2-N3FwfcQZngU_bM0KL3e4WpvWanC4chDjOfrQgIvm4ngn6OHr7aL6ls1_zL5X03mmRVn0mWI0F9AsiTCkUZRQLhko4HkpKBOciyaVZYwyRaBgWoJWKiFTLqlmwAo-QVeH3G3wv4dUrm5t1MY56IwfYp3zUqU0_q6QSqEKIVQS0oNQBx9jME29DbaFsKspqfd716_2Tp7LY_iwbM3qn-M4cOJfDtx2jQ8tPPngVnUPO-dDE6DTNu6j_x__-YV9bcD1aw3B1Bs_hC4N_Ea5P8v3nMo</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Rao, K. S.</creator><creator>Betso, J. E.</creator><creator>Olson, K. J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>A Collection of Guinea Pig Sensitization Test Results - Grouped by Chemical Class</title><author>Rao, K. S. ; Betso, J. E. ; Olson, K. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-62174afb04e0f6101352a6a3794124334f012221260a82c5ac66941e9b1c2a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Allergens</topic><topic>Animals</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Guinea Pigs - immunology</topic><topic>Male</topic><topic>Skin Tests</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, K. S.</creatorcontrib><creatorcontrib>Betso, J. E.</creatorcontrib><creatorcontrib>Olson, K. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, K. S.</au><au>Betso, J. E.</au><au>Olson, K. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Collection of Guinea Pig Sensitization Test Results - Grouped by Chemical Class</atitle><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle><addtitle>Drug Chem Toxicol</addtitle><date>1981</date><risdate>1981</risdate><volume>4</volume><issue>4</issue><spage>331</spage><epage>351</epage><pages>331-351</pages><issn>0148-0545</issn><eissn>1525-6014</eissn><abstract>ABSTRACT
Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions should be made with caution due to variability of sample purity or differences in methodology. It is important to realize that every chemical which is positive in the guinea pig should not be construed as definitive evidence of human skin sensitization.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>7344910</pmid><doi>10.3109/01480548109017825</doi><tpages>21</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-0545 |
| ispartof | Drug and chemical toxicology (New York, N.Y. 1978), 1981, Vol.4 (4), p.331-351 |
| issn | 0148-0545 1525-6014 |
| language | eng |
| recordid | cdi_pubmed_primary_7344910 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Allergens Animals Drug Evaluation, Preclinical - methods Guinea Pigs - immunology Male Skin Tests Structure-Activity Relationship |
| title | A Collection of Guinea Pig Sensitization Test Results - Grouped by Chemical Class |
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