Pharmacokinetics of vincristine sulfate in adult cancer patients

Vincristine concentration in serum from 1 min to 72 hr was measured by radioimmunoassay in 14 patients with cancers following i.v. bolus injection of vincristine sulfate at 0.45 to 1.30 mg/sq m. The pharmacokinetic data were analyzed by a nonlinear least-square regression program NONLIN. A three-com...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1981-09, Vol.41 (9 Pt 1), p.3551
Hauptverfasser:	Sethi, V S, Jackson, Jr, D V, White, D R, Richards, 2nd, F, Stuart, J J, Muss, H B, Cooper, M R, Spurr, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Dose-Response Relationship, Drug Female Half-Life Humans Injections, Intravenous Kinetics Male Metabolic Clearance Rate Middle Aged Neoplasms - drug therapy Nervous System Diseases - chemically induced Platelet Count Regression Analysis Vincristine - administration & dosage Vincristine - adverse effects Vincristine - blood
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