Chemotherapy of disseminated seminoma with combination of cis-diamminedichloroplatinum (II) and cyclophosphamide
Nine patients with metastatic seminoma who had received no prior chemotherapy were induced with a combination containing cis-platinum 120 mg/m2 I.V. and cyclophosphamide 600 mg/m2 I.V. for three to six treatments at 4-6 weeks intervals, and then received maintenance with cyclophosphamide 600 mg/m2 I...
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| Veröffentlicht in: | Cancer clinical trials 1981-01, Vol.4 (4), p.423 |
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| creator | Vugrin, D Whitemore, Jr, W J Batata, M |
| description | Nine patients with metastatic seminoma who had received no prior chemotherapy were induced with a combination containing cis-platinum 120 mg/m2 I.V. and cyclophosphamide 600 mg/m2 I.V. for three to six treatments at 4-6 weeks intervals, and then received maintenance with cyclophosphamide 600 mg/m2 I.V. every 3-4 weeks to complete 2 years of chemotherapy. Eight patients entered complete remission: five with chemotherapy alone and three with chemotherapy and radiation or resection of residual disease. Seven patients remain in CR with a minimum follow up of 17 months. Chemotherapy is effective in treatment of metastatic seminoma. |
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Eight patients entered complete remission: five with chemotherapy alone and three with chemotherapy and radiation or resection of residual disease. Seven patients remain in CR with a minimum follow up of 17 months. Chemotherapy is effective in treatment of metastatic seminoma.</description><identifier>ISSN: 0190-1206</identifier><identifier>PMID: 7198516</identifier><language>eng</language><publisher>United States</publisher><subject>Cisplatin - administration & dosage ; Cyclophosphamide - administration & dosage ; Drug Therapy, Combination ; Dysgerminoma - drug therapy ; Follow-Up Studies ; Humans ; Male ; Mediastinal Neoplasms - drug therapy ; Testicular Neoplasms - drug therapy</subject><ispartof>Cancer clinical trials, 1981-01, Vol.4 (4), p.423</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7198516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vugrin, D</creatorcontrib><creatorcontrib>Whitemore, Jr, W J</creatorcontrib><creatorcontrib>Batata, M</creatorcontrib><title>Chemotherapy of disseminated seminoma with combination of cis-diamminedichloroplatinum (II) and cyclophosphamide</title><title>Cancer clinical trials</title><addtitle>Cancer Clin Trials</addtitle><description>Nine patients with metastatic seminoma who had received no prior chemotherapy were induced with a combination containing cis-platinum 120 mg/m2 I.V. and cyclophosphamide 600 mg/m2 I.V. for three to six treatments at 4-6 weeks intervals, and then received maintenance with cyclophosphamide 600 mg/m2 I.V. every 3-4 weeks to complete 2 years of chemotherapy. Eight patients entered complete remission: five with chemotherapy alone and three with chemotherapy and radiation or resection of residual disease. Seven patients remain in CR with a minimum follow up of 17 months. 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Eight patients entered complete remission: five with chemotherapy alone and three with chemotherapy and radiation or resection of residual disease. Seven patients remain in CR with a minimum follow up of 17 months. Chemotherapy is effective in treatment of metastatic seminoma.</abstract><cop>United States</cop><pmid>7198516</pmid></addata></record> |
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| identifier | ISSN: 0190-1206 |
| ispartof | Cancer clinical trials, 1981-01, Vol.4 (4), p.423 |
| issn | 0190-1206 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Cisplatin - administration & dosage Cyclophosphamide - administration & dosage Drug Therapy, Combination Dysgerminoma - drug therapy Follow-Up Studies Humans Male Mediastinal Neoplasms - drug therapy Testicular Neoplasms - drug therapy |
| title | Chemotherapy of disseminated seminoma with combination of cis-diamminedichloroplatinum (II) and cyclophosphamide |
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