Toxicity and teratogenicity studies with the hypolipidemic drug RMI 14,514 in rats

The hypolipidemic drug RMI 14,514 (5-tetradecyloxy-2-furoic acid) has an oral LD50 of over 5000 mg/kg in rats. In a chronic toxicity study (6 months drug diet) doses of 30, 100, or 300 mg/kg/day produced no obvious signs of toxicity or abnormal clinical pathology parameters, other than prominent gro...

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Veröffentlicht in:	Fundamental and applied toxicology 1981-01, Vol.1 (1), p.19
Hauptverfasser:	Gibson, J P, Larson, E J, Yarrington, J T, Hook, R H, Kariya, T, Blohm, T R
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals Brain - metabolism Female Furans - metabolism Furans - toxicity Hypolipidemic Agents - toxicity Lipid Metabolism Liver - drug effects Male Microbodies - metabolism Pregnancy Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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