Demonstration of cross-reacting tumor rejection antigens in chemically induced respiratory tract carcinomas in rats

Demonstration of cross-reacting tumor rejection antigens in chemically induced respiratory tract carcinomas in rats

Experiments were performed to determine whether chemically induced rat respiratory tract carcinomas, which possess considerable immunogenicity, contain cross-reacting antigens. In vivo studies showed that effective cross-protection can be induced with four of the five respiratory tract cancers studi...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 1977-11, Vol.37 (11), p.4059
Hauptverfasser: Jamasbi, R J, Nettesheim, P
Format: Artikel
Sprache:eng
Schlagworte:
9,10-Dimethyl-1,2-benzanthracene
Animals
Antibodies, Neoplasm
Antigens, Neoplasm - analysis
Benzopyrenes
Carcinoma, Squamous Cell - immunology
Cell Line
Cross Reactions
Graft Rejection
In Vitro Techniques
Male
Neoplasm Transplantation
Neoplasms, Experimental - immunology
Rats
Rats, Inbred F344
Respiratory Tract Neoplasms - chemically induced
Respiratory Tract Neoplasms - immunology
RNA-Directed DNA Polymerase - analysis
Transplantation, Isogeneic
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Zusammenfassung:Experiments were performed to determine whether chemically induced rat respiratory tract carcinomas, which possess considerable immunogenicity, contain cross-reacting antigens. In vivo studies showed that effective cross-protection can be induced with four of the five respiratory tract cancers studied, suggesting that these tumors have common tumor rejection antigens. In vitro cytotoxicity studies with sera from tumor-immune hosts showed cross-reactivity among three of the carcinomas tested.
ISSN:0008-5472