The spin-lattice relaxation time in the blood of healthy subjects and patients with malignant blood disease
To establish which constituents of blood influence the NMR relaxation time T1 of water protons in malignant blood diseases, 55 blood samples were studied (20 from healthy donors and 35 from patients with leukaemia, myelofibrosis and multiple myeloma). Relaxation time measurements were performed at 1...
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| Veröffentlicht in: | Physics in medicine & biology 1982-07, Vol.27 (7), p.937-947 |
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| container_title | Physics in medicine & biology |
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| creator | Koivula, A Suominen, K Timonen, T Kiviniitty, K |
| description | To establish which constituents of blood influence the NMR relaxation time T1 of water protons in malignant blood diseases, 55 blood samples were studied (20 from healthy donors and 35 from patients with leukaemia, myelofibrosis and multiple myeloma). Relaxation time measurements were performed at 19.8 MHz resonance frequency and at a temperature of 33 +/- 1 degree C. There is a significant elevation of T1 over the normal level in whole blood, packed cells, and plasma of patients with blood disease. The relaxation rate R1 (= 1/T1) depends very strongly on the ratio of dry solids to water, which is in accordance with the three-state fast-exchange relaxation model. |
| doi_str_mv | 10.1088/0031-9155/27/7/005 |
| format | Article |
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Relaxation time measurements were performed at 19.8 MHz resonance frequency and at a temperature of 33 +/- 1 degree C. There is a significant elevation of T1 over the normal level in whole blood, packed cells, and plasma of patients with blood disease. The relaxation rate R1 (= 1/T1) depends very strongly on the ratio of dry solids to water, which is in accordance with the three-state fast-exchange relaxation model.</description><identifier>ISSN: 0031-9155</identifier><identifier>EISSN: 1361-6560</identifier><identifier>DOI: 10.1088/0031-9155/27/7/005</identifier><identifier>PMID: 7111398</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>Blood Physiological Phenomena ; Body Water - analysis ; Female ; Humans ; Leukemia - blood ; Magnetic Resonance Spectroscopy ; Male ; Multiple Myeloma - blood ; Primary Myelofibrosis - blood ; Time Factors</subject><ispartof>Physics in medicine & biology, 1982-07, Vol.27 (7), p.937-947</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-51e99d0a21ef41cc8c2fdb4b4fa75a0e56fb48c0d50160fe2147e17fe6caa9d73</citedby><cites>FETCH-LOGICAL-c370t-51e99d0a21ef41cc8c2fdb4b4fa75a0e56fb48c0d50160fe2147e17fe6caa9d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/0031-9155/27/7/005/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,27901,27902,53805,53885</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7111398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koivula, A</creatorcontrib><creatorcontrib>Suominen, K</creatorcontrib><creatorcontrib>Timonen, T</creatorcontrib><creatorcontrib>Kiviniitty, K</creatorcontrib><title>The spin-lattice relaxation time in the blood of healthy subjects and patients with malignant blood disease</title><title>Physics in medicine & biology</title><addtitle>Phys Med Biol</addtitle><description>To establish which constituents of blood influence the NMR relaxation time T1 of water protons in malignant blood diseases, 55 blood samples were studied (20 from healthy donors and 35 from patients with leukaemia, myelofibrosis and multiple myeloma). Relaxation time measurements were performed at 19.8 MHz resonance frequency and at a temperature of 33 +/- 1 degree C. There is a significant elevation of T1 over the normal level in whole blood, packed cells, and plasma of patients with blood disease. The relaxation rate R1 (= 1/T1) depends very strongly on the ratio of dry solids to water, which is in accordance with the three-state fast-exchange relaxation model.</description><subject>Blood Physiological Phenomena</subject><subject>Body Water - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia - blood</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Multiple Myeloma - blood</subject><subject>Primary Myelofibrosis - blood</subject><subject>Time Factors</subject><issn>0031-9155</issn><issn>1361-6560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOo7-AUHISnBRJ7dtmnYp4gsG3IzrkCY3TrQvmxT135thhtkIri6H851z4RByAewGWFkuGMsgqYDzRSoWIkp-QGaQFZAUvGCHZLYHTsip9--MAZRpfkyOBQBkVTkjH6s1Uj-4LmlUCE4jHbFR3yq4vqPBtUhdvJGpm743tLd0jaoJ6x_qp_oddfBUdYYOMYBdFF8urGmrGvfWqS7sUsZ5VB7PyJFVjcfz3Z2T14f71d1Tsnx5fL67XSY6EywkHLCqDFMpoM1B61Kn1tR5nVsluGLIC1vnpWaGMyiYxRRygSAsFlqpyohsTq62vcPYf07og2yd19g0qsN-8lLkIHJRphFMt6Aee-9HtHIYXavGHwlMbhaWmwHlZkCZCimi5DF0uWuf6hbNPrKbNPrXW9_1w9782yMHYyOb_GX_-f0L5v-SrQ</recordid><startdate>198207</startdate><enddate>198207</enddate><creator>Koivula, A</creator><creator>Suominen, K</creator><creator>Timonen, T</creator><creator>Kiviniitty, K</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198207</creationdate><title>The spin-lattice relaxation time in the blood of healthy subjects and patients with malignant blood disease</title><author>Koivula, A ; Suominen, K ; Timonen, T ; Kiviniitty, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-51e99d0a21ef41cc8c2fdb4b4fa75a0e56fb48c0d50160fe2147e17fe6caa9d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Blood Physiological Phenomena</topic><topic>Body Water - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia - blood</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Multiple Myeloma - blood</topic><topic>Primary Myelofibrosis - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koivula, A</creatorcontrib><creatorcontrib>Suominen, K</creatorcontrib><creatorcontrib>Timonen, T</creatorcontrib><creatorcontrib>Kiviniitty, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physics in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koivula, A</au><au>Suominen, K</au><au>Timonen, T</au><au>Kiviniitty, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The spin-lattice relaxation time in the blood of healthy subjects and patients with malignant blood disease</atitle><jtitle>Physics in medicine & biology</jtitle><addtitle>Phys Med Biol</addtitle><date>1982-07</date><risdate>1982</risdate><volume>27</volume><issue>7</issue><spage>937</spage><epage>947</epage><pages>937-947</pages><issn>0031-9155</issn><eissn>1361-6560</eissn><abstract>To establish which constituents of blood influence the NMR relaxation time T1 of water protons in malignant blood diseases, 55 blood samples were studied (20 from healthy donors and 35 from patients with leukaemia, myelofibrosis and multiple myeloma). Relaxation time measurements were performed at 19.8 MHz resonance frequency and at a temperature of 33 +/- 1 degree C. There is a significant elevation of T1 over the normal level in whole blood, packed cells, and plasma of patients with blood disease. The relaxation rate R1 (= 1/T1) depends very strongly on the ratio of dry solids to water, which is in accordance with the three-state fast-exchange relaxation model.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>7111398</pmid><doi>10.1088/0031-9155/27/7/005</doi><tpages>11</tpages></addata></record> |
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| ispartof | Physics in medicine & biology, 1982-07, Vol.27 (7), p.937-947 |
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| language | eng |
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| source | Institute of Physics Journals; MEDLINE; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Blood Physiological Phenomena Body Water - analysis Female Humans Leukemia - blood Magnetic Resonance Spectroscopy Male Multiple Myeloma - blood Primary Myelofibrosis - blood Time Factors |
| title | The spin-lattice relaxation time in the blood of healthy subjects and patients with malignant blood disease |
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