Putrescine as a regulator of ε-(γ-glutamyl) lysine isopeptide production and the proliferative state

Putrescine as a regulator of ε-(γ-glutamyl) lysine isopeptide production and the proliferative state

Transglutaminase-catalyzed isopeptide bond formation in human cell homogenates was inhibited by putrescine. Limitation of putrescine biosynthesis in proliferating cells by 1, 3-diaminopropanol resulted in growth inhibition and increased cellular isopeptide content. A correlation of isopeptide conten...

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Veröffentlicht in:Cell biology international reports 1982-01, Vol.6 (5), p.461-470
Hauptverfasser: Patterson, M.K., Maxwell, M.D., Birckbichler, P.J., Conway, E., Carter, H.A.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Division - drug effects
Cell Line
Dipeptides - biosynthesis
Humans
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Zusammenfassung:Transglutaminase-catalyzed isopeptide bond formation in human cell homogenates was inhibited by putrescine. Limitation of putrescine biosynthesis in proliferating cells by 1, 3-diaminopropanol resulted in growth inhibition and increased cellular isopeptide content. A correlation of isopeptide content, polyamine levels, and the proliferative state was found.
ISSN:0309-1651
1878-240X
DOI:10.1016/0309-1651(82)90118-7