Study of Rimantadine in the USSR: A Review of the Literature
The results of basic-science and clinical studies performed in the USSR with the drug rimantadine are summarized. In the investigations cited, the therapeutic and prophylactic efficacy of rimantadine against infection with influenza virus was tested, and rimantadine was shown to be clinically effica...
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| Veröffentlicht in: | Reviews of infectious diseases 1981-05, Vol.3 (3), p.408-421 |
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| container_title | Reviews of infectious diseases |
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| creator | Zlydnikov, D M Kubar, O I Kovaleva, T P Kamforin, L E |
| description | The results of basic-science and clinical studies performed in the USSR with the drug rimantadine are summarized. In the investigations cited, the therapeutic and prophylactic efficacy of rimantadine against infection with influenza virus was tested, and rimantadine was shown to be clinically efficacious and free of toxicity, both in studies with volunteers and in persons with natural disease during epidemics of influenza. Administration of 50 mg of the drug for 15-30 days was effective for prevention of influenza, and administration, early in the course of illness, of dosage of 150 mg per day for three to five days resulted in a favorable clinical response. The combination of immunization and chemoprophylaxis was shown to be highly effective for the prevention of influenza. |
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In the investigations cited, the therapeutic and prophylactic efficacy of rimantadine against infection with influenza virus was tested, and rimantadine was shown to be clinically efficacious and free of toxicity, both in studies with volunteers and in persons with natural disease during epidemics of influenza. Administration of 50 mg of the drug for 15-30 days was effective for prevention of influenza, and administration, early in the course of illness, of dosage of 150 mg per day for three to five days resulted in a favorable clinical response. The combination of immunization and chemoprophylaxis was shown to be highly effective for the prevention of influenza.</description><identifier>ISSN: 0162-0886</identifier><identifier>PMID: 7025146</identifier><language>eng</language><publisher>United States: University of Chicago Press</publisher><subject>Adamantane - analogs & derivatives ; Amantadine - therapeutic use ; Antivirals ; Chemoprevention ; Chemotherapy ; Clinical Trials as Topic ; Dosage ; Double-Blind Method ; Epidemics ; Human experimentation ; Humans ; Influenza Vaccines - administration & dosage ; Influenza, Human - drug therapy ; Influenza, Human - prevention & control ; Medical treatment ; Orthomyxoviridae ; Orthomyxoviridae - genetics ; Placebos ; Review Articles ; Rimantadine - therapeutic use ; RNA Replicase - antagonists & inhibitors ; Transcription, Genetic - drug effects ; USSR ; Viruses</subject><ispartof>Reviews of infectious diseases, 1981-05, Vol.3 (3), p.408-421</ispartof><rights>Copyright 1981 The University of Chicago</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4452575$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4452575$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7025146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zlydnikov, D M</creatorcontrib><creatorcontrib>Kubar, O I</creatorcontrib><creatorcontrib>Kovaleva, T P</creatorcontrib><creatorcontrib>Kamforin, L E</creatorcontrib><title>Study of Rimantadine in the USSR: A Review of the Literature</title><title>Reviews of infectious diseases</title><addtitle>Rev Infect Dis</addtitle><description>The results of basic-science and clinical studies performed in the USSR with the drug rimantadine are summarized. In the investigations cited, the therapeutic and prophylactic efficacy of rimantadine against infection with influenza virus was tested, and rimantadine was shown to be clinically efficacious and free of toxicity, both in studies with volunteers and in persons with natural disease during epidemics of influenza. Administration of 50 mg of the drug for 15-30 days was effective for prevention of influenza, and administration, early in the course of illness, of dosage of 150 mg per day for three to five days resulted in a favorable clinical response. 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In the investigations cited, the therapeutic and prophylactic efficacy of rimantadine against infection with influenza virus was tested, and rimantadine was shown to be clinically efficacious and free of toxicity, both in studies with volunteers and in persons with natural disease during epidemics of influenza. Administration of 50 mg of the drug for 15-30 days was effective for prevention of influenza, and administration, early in the course of illness, of dosage of 150 mg per day for three to five days resulted in a favorable clinical response. The combination of immunization and chemoprophylaxis was shown to be highly effective for the prevention of influenza.</abstract><cop>United States</cop><pub>University of Chicago Press</pub><pmid>7025146</pmid><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 0162-0886 |
| ispartof | Reviews of infectious diseases, 1981-05, Vol.3 (3), p.408-421 |
| issn | 0162-0886 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adamantane - analogs & derivatives Amantadine - therapeutic use Antivirals Chemoprevention Chemotherapy Clinical Trials as Topic Dosage Double-Blind Method Epidemics Human experimentation Humans Influenza Vaccines - administration & dosage Influenza, Human - drug therapy Influenza, Human - prevention & control Medical treatment Orthomyxoviridae Orthomyxoviridae - genetics Placebos Review Articles Rimantadine - therapeutic use RNA Replicase - antagonists & inhibitors Transcription, Genetic - drug effects USSR Viruses |
| title | Study of Rimantadine in the USSR: A Review of the Literature |
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