Carcinogenicity of Tannin and Tannin-Free Extracts of Bracken Fern (Pteridium aquilinum) in Rats
F344 inbred and Sprague-Dawley noninbred rats were fed a basic diet (groups 1 and 7) or a basic diet supplemented with 0.1% (later. 0.2 and 0.4%) tarinin (group 2) isolated from bracken fern (Pteridium aquilinum) (BF), 33% BF (groups 3 and 6), 2% chloroform fraction of BF (group 4), or 4% tannin-fre...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1980-07, Vol.65 (1), p.131-136 |
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| creator | Mahir Pamukcu, A. Wang, Ching Yung Hatcher, J. Bryan, George T. |
| description | F344 inbred and Sprague-Dawley noninbred rats were fed a basic diet (groups 1 and 7) or a basic diet supplemented with 0.1% (later. 0.2 and 0.4%) tarinin (group 2) isolated from bracken fern (Pteridium aquilinum) (BF), 33% BF (groups 3 and 6), 2% chloroform fraction of BF (group 4), or 4% tannin-free fraction of BF (group 5). The following incidences of intestinal or bladder tumors were observed: group 1, intestinal and bladder, 0/16; group 2. 0/21; group 7, 0/16; groups 4 and 5, intestinal, 7/15, bladder. 0/15; group 3, intestinal, 19/20, bladder, 12/20; and group 6, intestinal, 22/30. bladder. 15/30. The chloroform- methanol fraction prepared from urine of rats fed BF, chloroform fraction of BF, or tannin-free fraction of BF demonstrated mutagenicity for Salmonella typhimurium TA 100 but not for TA 98. No mutagenicity was detected in other prepared fractions. F344 rats in group 8 received weekly sc injections of tannin solution (0.1 g/kg body wt) for 38 weeks, and 16/20 developed palpable tumors that were malignant fibrous histiocytomas at the injection site. No tumor was present in any rat of control group 9. |
| doi_str_mv | 10.1093/jnci/65.1.131 |
| format | Article |
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The following incidences of intestinal or bladder tumors were observed: group 1, intestinal and bladder, 0/16; group 2. 0/21; group 7, 0/16; groups 4 and 5, intestinal, 7/15, bladder. 0/15; group 3, intestinal, 19/20, bladder, 12/20; and group 6, intestinal, 22/30. bladder. 15/30. The chloroform- methanol fraction prepared from urine of rats fed BF, chloroform fraction of BF, or tannin-free fraction of BF demonstrated mutagenicity for Salmonella typhimurium TA 100 but not for TA 98. No mutagenicity was detected in other prepared fractions. F344 rats in group 8 received weekly sc injections of tannin solution (0.1 g/kg body wt) for 38 weeks, and 16/20 developed palpable tumors that were malignant fibrous histiocytomas at the injection site. No tumor was present in any rat of control group 9.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/65.1.131</identifier><identifier>PMID: 6993743</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Carcinogens ; Female ; Injections, Subcutaneous ; Intestinal Neoplasms - chemically induced ; Male ; Mutagens ; Plants, Edible ; Plants, Toxic ; Quercetin - toxicity ; Rats ; Salmonella typhimurium - drug effects ; Tannins - administration & dosage ; Tannins - toxicity ; Tannins - urine ; Urinary Bladder Neoplasms - chemically induced</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1980-07, Vol.65 (1), p.131-136</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6993743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahir Pamukcu, A.</creatorcontrib><creatorcontrib>Wang, Ching Yung</creatorcontrib><creatorcontrib>Hatcher, J.</creatorcontrib><creatorcontrib>Bryan, George T.</creatorcontrib><title>Carcinogenicity of Tannin and Tannin-Free Extracts of Bracken Fern (Pteridium aquilinum) in Rats</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>F344 inbred and Sprague-Dawley noninbred rats were fed a basic diet (groups 1 and 7) or a basic diet supplemented with 0.1% (later. 0.2 and 0.4%) tarinin (group 2) isolated from bracken fern (Pteridium aquilinum) (BF), 33% BF (groups 3 and 6), 2% chloroform fraction of BF (group 4), or 4% tannin-free fraction of BF (group 5). The following incidences of intestinal or bladder tumors were observed: group 1, intestinal and bladder, 0/16; group 2. 0/21; group 7, 0/16; groups 4 and 5, intestinal, 7/15, bladder. 0/15; group 3, intestinal, 19/20, bladder, 12/20; and group 6, intestinal, 22/30. bladder. 15/30. The chloroform- methanol fraction prepared from urine of rats fed BF, chloroform fraction of BF, or tannin-free fraction of BF demonstrated mutagenicity for Salmonella typhimurium TA 100 but not for TA 98. No mutagenicity was detected in other prepared fractions. F344 rats in group 8 received weekly sc injections of tannin solution (0.1 g/kg body wt) for 38 weeks, and 16/20 developed palpable tumors that were malignant fibrous histiocytomas at the injection site. No tumor was present in any rat of control group 9.</description><subject>Animals</subject><subject>Carcinogens</subject><subject>Female</subject><subject>Injections, Subcutaneous</subject><subject>Intestinal Neoplasms - chemically induced</subject><subject>Male</subject><subject>Mutagens</subject><subject>Plants, Edible</subject><subject>Plants, Toxic</subject><subject>Quercetin - toxicity</subject><subject>Rats</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Tannins - administration & dosage</subject><subject>Tannins - toxicity</subject><subject>Tannins - urine</subject><subject>Urinary Bladder Neoplasms - chemically induced</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01PwkAYhDdGg4gePZrsUQ8L-9ltj9qAGEn8CBrDpb60W7NAF9huE_j31kCcy0zyTCYZhK4Z7TOaiMHC5XYQqT7rM8FOUJfJiBLOqDpFXUq5JnGs5Tm6qOsFbZVw2UGdKEmElqKLvlPwuXXrH-NsbsMer0s8Beesw-CKYyQjbwwe7oKHPNR_lYc2LY3DI-Mdvn0NxtvCNhWGbWNX1jXVHW4X3iHUl-ishFVtro7eQx-j4TQdk8nL41N6PyGWSxkISzQYlQDnlMVcQyJBc1pIBVSIWEVaRmKuYiPmgueUSWDMcKVkGce5KVkkeujmsLtp5pUpso23Ffh9dnzacnLgtg5m94_BL7NIC62y8dcsE5Pn9HM8e8uY-AW8BWNk</recordid><startdate>198007</startdate><enddate>198007</enddate><creator>Mahir Pamukcu, A.</creator><creator>Wang, Ching Yung</creator><creator>Hatcher, J.</creator><creator>Bryan, George T.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198007</creationdate><title>Carcinogenicity of Tannin and Tannin-Free Extracts of Bracken Fern (Pteridium aquilinum) in Rats</title><author>Mahir Pamukcu, A. ; Wang, Ching Yung ; Hatcher, J. ; Bryan, George T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i244t-197ae59a2201827a94a720d45a0338567463b58e3b32c014a11e2554f88cef163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Carcinogens</topic><topic>Female</topic><topic>Injections, Subcutaneous</topic><topic>Intestinal Neoplasms - chemically induced</topic><topic>Male</topic><topic>Mutagens</topic><topic>Plants, Edible</topic><topic>Plants, Toxic</topic><topic>Quercetin - toxicity</topic><topic>Rats</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Tannins - administration & dosage</topic><topic>Tannins - toxicity</topic><topic>Tannins - urine</topic><topic>Urinary Bladder Neoplasms - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahir Pamukcu, A.</creatorcontrib><creatorcontrib>Wang, Ching Yung</creatorcontrib><creatorcontrib>Hatcher, J.</creatorcontrib><creatorcontrib>Bryan, George T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahir Pamukcu, A.</au><au>Wang, Ching Yung</au><au>Hatcher, J.</au><au>Bryan, George T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinogenicity of Tannin and Tannin-Free Extracts of Bracken Fern (Pteridium aquilinum) in Rats</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1980-07</date><risdate>1980</risdate><volume>65</volume><issue>1</issue><spage>131</spage><epage>136</epage><pages>131-136</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>F344 inbred and Sprague-Dawley noninbred rats were fed a basic diet (groups 1 and 7) or a basic diet supplemented with 0.1% (later. 0.2 and 0.4%) tarinin (group 2) isolated from bracken fern (Pteridium aquilinum) (BF), 33% BF (groups 3 and 6), 2% chloroform fraction of BF (group 4), or 4% tannin-free fraction of BF (group 5). The following incidences of intestinal or bladder tumors were observed: group 1, intestinal and bladder, 0/16; group 2. 0/21; group 7, 0/16; groups 4 and 5, intestinal, 7/15, bladder. 0/15; group 3, intestinal, 19/20, bladder, 12/20; and group 6, intestinal, 22/30. bladder. 15/30. The chloroform- methanol fraction prepared from urine of rats fed BF, chloroform fraction of BF, or tannin-free fraction of BF demonstrated mutagenicity for Salmonella typhimurium TA 100 but not for TA 98. No mutagenicity was detected in other prepared fractions. F344 rats in group 8 received weekly sc injections of tannin solution (0.1 g/kg body wt) for 38 weeks, and 16/20 developed palpable tumors that were malignant fibrous histiocytomas at the injection site. No tumor was present in any rat of control group 9.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>6993743</pmid><doi>10.1093/jnci/65.1.131</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1980-07, Vol.65 (1), p.131-136 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Carcinogens Female Injections, Subcutaneous Intestinal Neoplasms - chemically induced Male Mutagens Plants, Edible Plants, Toxic Quercetin - toxicity Rats Salmonella typhimurium - drug effects Tannins - administration & dosage Tannins - toxicity Tannins - urine Urinary Bladder Neoplasms - chemically induced |
| title | Carcinogenicity of Tannin and Tannin-Free Extracts of Bracken Fern (Pteridium aquilinum) in Rats |
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