Immunomodulating and Antimetastatic Activity of 3-(P-Chlorophenyl) Thiazolo[3, 2-A]Benzimidazole-2-Acetic Acid (Wy-18, 251, Nsc 310633)

Abstract The antimetastatic activity of a thiazolobenzimidazole, Wy-18, 251 was investigated using various dosage regimens in mice with implanted Lewis lung tumors. The low doses, 1 and 5 mg/kg (i.p.) given 24 hours after implantation with two subsequent doses at 1 week intervals were most effective...

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Veröffentlicht in:	Immunopharmacology and immunotoxicology 1980, Vol.2 (4), p.491-508
Hauptverfasser:	Fenichel, R. L., Alburn, H. E., Schreck, P. A., Bloom, R., Gregory, F. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology B-Lymphocytes - drug effects Benzimidazoles - pharmacology Cell Division - drug effects Immunity - drug effects Leukemia P388 - drug therapy Lung Neoplasms - drug therapy Mice Neoplasm Metastasis - prevention & control Neoplasms, Experimental - drug therapy Rosette Formation T-Lymphocytes - drug effects
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