Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field
1. The serum concentration of cefmetazole (CMZ) was 56.8 +/- 13.3 micrograms/ml at 1 hour after one-shot intravenous injection of 2 g. Half-life was 1.1 hours, indicating that the drug is adsorbed rapidly. In addition, CMZ was detected at high concentrations in the endometrium, myometrium, ovary, ut...
Gespeichert in:
| Veröffentlicht in: | Japanese journal of antibiotics 1982-08, Vol.35 (8), p.1951 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 1951 |
| container_title | Japanese journal of antibiotics |
| container_volume | 35 |
| creator | Doko, F |
| description | 1. The serum concentration of cefmetazole (CMZ) was 56.8 +/- 13.3 micrograms/ml at 1 hour after one-shot intravenous injection of 2 g. Half-life was 1.1 hours, indicating that the drug is adsorbed rapidly. In addition, CMZ was detected at high concentrations in the endometrium, myometrium, ovary, uterine tube and cervix uteri. The concentration was especially high in the uterine tube and ovary. It was also demonstrated in the fetus and fetal membrane, though at low concentration. 2. Clinically one-shot intravenous injection of 1 to 2 g of CMZ were given 2 times daily to 15 patients with intrauterine infection, adnexitis, intrapelvic infection or postoperative wound infection. The drug was evaluated to be effective in 15 or 80% of them. No special side effects were found. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_6961239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>6961239</sourcerecordid><originalsourceid>FETCH-LOGICAL-p539-f4648e94f5b19e6b47cd8709d2b6e8d241aec4e1be19b44e5358796861c4a9433</originalsourceid><addsrcrecordid>eNotj8lqwzAURbVoSUOaTwjoBwzWYFlahtAJAs0ie6PhyRXIkrHUQvr1DWlWd3G4B84DWrdMyIb2kjyhbSnBtC2VlCjVrdBKKEEoU2s0nBaIYQpJLxesk8M2hhSsjjikHyg1jLqGnArOHlvwE1T9myNcKa5fgLMpFeoS7O07XhLYHPN4E_gA0T2jR69jge19N-j8-nI-vDfHz7ePw_7YzB1TjeeCS1Dcd4YoEIb31sm-VY4aAdJRTjRYDsQAUYZz6FgneyWkIJZrxRnboN2_dv42E7hhXsJ0LRrunewPl1RQTQ</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Doko, F</creator><creatorcontrib>Doko, F</creatorcontrib><description>1. The serum concentration of cefmetazole (CMZ) was 56.8 +/- 13.3 micrograms/ml at 1 hour after one-shot intravenous injection of 2 g. Half-life was 1.1 hours, indicating that the drug is adsorbed rapidly. In addition, CMZ was detected at high concentrations in the endometrium, myometrium, ovary, uterine tube and cervix uteri. The concentration was especially high in the uterine tube and ovary. It was also demonstrated in the fetus and fetal membrane, though at low concentration. 2. Clinically one-shot intravenous injection of 1 to 2 g of CMZ were given 2 times daily to 15 patients with intrauterine infection, adnexitis, intrapelvic infection or postoperative wound infection. The drug was evaluated to be effective in 15 or 80% of them. No special side effects were found.</description><identifier>ISSN: 0368-2781</identifier><identifier>PMID: 6961239</identifier><language>jpn</language><publisher>Japan</publisher><subject>Adult ; Aged ; Bacterial Infections - drug therapy ; Cefmetazole ; Cephalosporins - metabolism ; Cephamycins - administration & dosage ; Cephamycins - adverse effects ; Cephamycins - metabolism ; Cephamycins - therapeutic use ; Drug Evaluation ; Female ; Genital Diseases, Female - drug therapy ; Genitalia, Female - metabolism ; Humans ; Injections, Intravenous ; Middle Aged ; Tissue Distribution</subject><ispartof>Japanese journal of antibiotics, 1982-08, Vol.35 (8), p.1951</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6961239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doko, F</creatorcontrib><title>Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field</title><title>Japanese journal of antibiotics</title><addtitle>Jpn J Antibiot</addtitle><description>1. The serum concentration of cefmetazole (CMZ) was 56.8 +/- 13.3 micrograms/ml at 1 hour after one-shot intravenous injection of 2 g. Half-life was 1.1 hours, indicating that the drug is adsorbed rapidly. In addition, CMZ was detected at high concentrations in the endometrium, myometrium, ovary, uterine tube and cervix uteri. The concentration was especially high in the uterine tube and ovary. It was also demonstrated in the fetus and fetal membrane, though at low concentration. 2. Clinically one-shot intravenous injection of 1 to 2 g of CMZ were given 2 times daily to 15 patients with intrauterine infection, adnexitis, intrapelvic infection or postoperative wound infection. The drug was evaluated to be effective in 15 or 80% of them. No special side effects were found.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial Infections - drug therapy</subject><subject>Cefmetazole</subject><subject>Cephalosporins - metabolism</subject><subject>Cephamycins - administration & dosage</subject><subject>Cephamycins - adverse effects</subject><subject>Cephamycins - metabolism</subject><subject>Cephamycins - therapeutic use</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Genital Diseases, Female - drug therapy</subject><subject>Genitalia, Female - metabolism</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Middle Aged</subject><subject>Tissue Distribution</subject><issn>0368-2781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj8lqwzAURbVoSUOaTwjoBwzWYFlahtAJAs0ie6PhyRXIkrHUQvr1DWlWd3G4B84DWrdMyIb2kjyhbSnBtC2VlCjVrdBKKEEoU2s0nBaIYQpJLxesk8M2hhSsjjikHyg1jLqGnArOHlvwE1T9myNcKa5fgLMpFeoS7O07XhLYHPN4E_gA0T2jR69jge19N-j8-nI-vDfHz7ePw_7YzB1TjeeCS1Dcd4YoEIb31sm-VY4aAdJRTjRYDsQAUYZz6FgneyWkIJZrxRnboN2_dv42E7hhXsJ0LRrunewPl1RQTQ</recordid><startdate>198208</startdate><enddate>198208</enddate><creator>Doko, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198208</creationdate><title>Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field</title><author>Doko, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p539-f4648e94f5b19e6b47cd8709d2b6e8d241aec4e1be19b44e5358796861c4a9433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacterial Infections - drug therapy</topic><topic>Cefmetazole</topic><topic>Cephalosporins - metabolism</topic><topic>Cephamycins - administration & dosage</topic><topic>Cephamycins - adverse effects</topic><topic>Cephamycins - metabolism</topic><topic>Cephamycins - therapeutic use</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Genital Diseases, Female - drug therapy</topic><topic>Genitalia, Female - metabolism</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Middle Aged</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doko, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doko, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn J Antibiot</addtitle><date>1982-08</date><risdate>1982</risdate><volume>35</volume><issue>8</issue><spage>1951</spage><pages>1951-</pages><issn>0368-2781</issn><abstract>1. The serum concentration of cefmetazole (CMZ) was 56.8 +/- 13.3 micrograms/ml at 1 hour after one-shot intravenous injection of 2 g. Half-life was 1.1 hours, indicating that the drug is adsorbed rapidly. In addition, CMZ was detected at high concentrations in the endometrium, myometrium, ovary, uterine tube and cervix uteri. The concentration was especially high in the uterine tube and ovary. It was also demonstrated in the fetus and fetal membrane, though at low concentration. 2. Clinically one-shot intravenous injection of 1 to 2 g of CMZ were given 2 times daily to 15 patients with intrauterine infection, adnexitis, intrapelvic infection or postoperative wound infection. The drug was evaluated to be effective in 15 or 80% of them. No special side effects were found.</abstract><cop>Japan</cop><pmid>6961239</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | Japanese journal of antibiotics, 1982-08, Vol.35 (8), p.1951 |
| issn | 0368-2781 |
| language | jpn |
| recordid | cdi_pubmed_primary_6961239 |
| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adult Aged Bacterial Infections - drug therapy Cefmetazole Cephalosporins - metabolism Cephamycins - administration & dosage Cephamycins - adverse effects Cephamycins - metabolism Cephamycins - therapeutic use Drug Evaluation Female Genital Diseases, Female - drug therapy Genitalia, Female - metabolism Humans Injections, Intravenous Middle Aged Tissue Distribution |
| title | Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T11%3A06%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preliminary%20and%20clinical%20investigations%20of%20cefmetazole%20in%20the%20obstetric%20and%20gynecological%20field&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=Doko,%20F&rft.date=1982-08&rft.volume=35&rft.issue=8&rft.spage=1951&rft.pages=1951-&rft.issn=0368-2781&rft_id=info:doi/&rft_dat=%3Cpubmed%3E6961239%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/6961239&rfr_iscdi=true |