Mathematical and Clinical Investigation of the RP6-Rhodial 75 System: Evaluation of High and Low Middle Molecular Clearance Dialysis
The clearance for "middle molecules" measured in vitro was considerably higher for a polyacrylonitrile than for a cuprophan membrane, even when the former had been used for patients three times. Using a two pool mathematical model, an adequate correlation was found between the calculated v...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1978-01, Vol.12 (2), p.167-174 |
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| container_end_page | 174 |
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| container_issue | 2 |
| container_start_page | 167 |
| container_title | Scandinavian journal of urology and nephrology |
| container_volume | 12 |
| creator | Jørstad, S. Widerøe, T.-E. Smedby, L. Berg, K. J. Wicks, K. |
| description | The clearance for "middle molecules" measured in vitro was considerably higher for a polyacrylonitrile than for a cuprophan membrane, even when the former had been used for patients three times. Using a two pool mathematical model, an adequate correlation was found between the calculated values and those measured during RP6-Rhodial 75 dialysis (RP6). The treatment time needed for dialysis of "middle molecules" with the Gambro 13.5μ in single pass (Gambro S. P.) was four times longer than with RP6. In a long-term clinical study, when RP6 and Gambro S. P. dialysis were compared, no difference in the clinical condition of the patients was found. Clinical condition was not affected by the urea or "middle molecule" levels. The ultrafiltration tolerance was improved during hemodialysis with systems resulting in a low urea clearance. |
| doi_str_mv | 10.3109/00365597809179987 |
| format | Article |
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The ultrafiltration tolerance was improved during hemodialysis with systems resulting in a low urea clearance.</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365597809179987</identifier><identifier>PMID: 694443</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acrylonitrile ; Computers ; Creatinine - blood ; Evaluation Studies as Topic ; Humans ; Kidneys, Artificial ; Mathematics ; Membranes, Artificial ; Models, Theoretical ; Potassium - blood ; Renal Dialysis - methods ; Time Factors ; Toxins, Biological - blood ; Ultrafiltration ; Urea - blood ; Uremia - blood ; Uremia - therapy</subject><ispartof>Scandinavian journal of urology and nephrology, 1978-01, Vol.12 (2), p.167-174</ispartof><rights>1978 Informa UK Ltd 1978</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-ce6775964787348613e1189e0e8bc41ba31168bb7b925e8afd4d283bbe31706c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365597809179987$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365597809179987$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/694443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jørstad, S.</creatorcontrib><creatorcontrib>Widerøe, T.-E.</creatorcontrib><creatorcontrib>Smedby, L.</creatorcontrib><creatorcontrib>Berg, K. J.</creatorcontrib><creatorcontrib>Wicks, K.</creatorcontrib><title>Mathematical and Clinical Investigation of the RP6-Rhodial 75 System: Evaluation of High and Low Middle Molecular Clearance Dialysis</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>The clearance for "middle molecules" measured in vitro was considerably higher for a polyacrylonitrile than for a cuprophan membrane, even when the former had been used for patients three times. Using a two pool mathematical model, an adequate correlation was found between the calculated values and those measured during RP6-Rhodial 75 dialysis (RP6). The treatment time needed for dialysis of "middle molecules" with the Gambro 13.5μ in single pass (Gambro S. P.) was four times longer than with RP6. In a long-term clinical study, when RP6 and Gambro S. P. dialysis were compared, no difference in the clinical condition of the patients was found. Clinical condition was not affected by the urea or "middle molecule" levels. The ultrafiltration tolerance was improved during hemodialysis with systems resulting in a low urea clearance.</description><subject>Acrylonitrile</subject><subject>Computers</subject><subject>Creatinine - blood</subject><subject>Evaluation Studies as Topic</subject><subject>Humans</subject><subject>Kidneys, Artificial</subject><subject>Mathematics</subject><subject>Membranes, Artificial</subject><subject>Models, Theoretical</subject><subject>Potassium - blood</subject><subject>Renal Dialysis - methods</subject><subject>Time Factors</subject><subject>Toxins, Biological - blood</subject><subject>Ultrafiltration</subject><subject>Urea - blood</subject><subject>Uremia - blood</subject><subject>Uremia - therapy</subject><issn>0036-5599</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKxDAUhoN4G0cfQHDRF6jmNHdwI-MVRpRR1yVJUyfSNkNSlXl7O1bciKvD4fv-f_EjdAz4lABWZxgTzpgSEisQSkmxhSbAGeQF5mwbTTY8HwS1jw5SesMYFxz4HtrlilJKJujyXvdL1-reW91kuquyWeO77-eu-3Cp968DC10W6mwQs8UjzxfLUPlBECx7WqfetYdop9ZNckc_d4perq-eZ7f5_OHmbnYxzy3BuM-t40IwxamQglDJgTgAqRx20lgKRhMALo0RRhXMSV1XtCokMcYREJhbMkUw9toYUoquLlfRtzquS8DlZo_yzx5D5mTMrN5N66rfxDjAgM9H7Ls6xFZ_hthUZa_XTYh11J31adP8X_sX7lJr1w</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Jørstad, S.</creator><creator>Widerøe, T.-E.</creator><creator>Smedby, L.</creator><creator>Berg, K. J.</creator><creator>Wicks, K.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19780101</creationdate><title>Mathematical and Clinical Investigation of the RP6-Rhodial 75 System</title><author>Jørstad, S. ; Widerøe, T.-E. ; Smedby, L. ; Berg, K. J. ; Wicks, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-ce6775964787348613e1189e0e8bc41ba31168bb7b925e8afd4d283bbe31706c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Acrylonitrile</topic><topic>Computers</topic><topic>Creatinine - blood</topic><topic>Evaluation Studies as Topic</topic><topic>Humans</topic><topic>Kidneys, Artificial</topic><topic>Mathematics</topic><topic>Membranes, Artificial</topic><topic>Models, Theoretical</topic><topic>Potassium - blood</topic><topic>Renal Dialysis - methods</topic><topic>Time Factors</topic><topic>Toxins, Biological - blood</topic><topic>Ultrafiltration</topic><topic>Urea - blood</topic><topic>Uremia - blood</topic><topic>Uremia - therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Jørstad, S.</creatorcontrib><creatorcontrib>Widerøe, T.-E.</creatorcontrib><creatorcontrib>Smedby, L.</creatorcontrib><creatorcontrib>Berg, K. J.</creatorcontrib><creatorcontrib>Wicks, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Scandinavian journal of urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jørstad, S.</au><au>Widerøe, T.-E.</au><au>Smedby, L.</au><au>Berg, K. J.</au><au>Wicks, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mathematical and Clinical Investigation of the RP6-Rhodial 75 System: Evaluation of High and Low Middle Molecular Clearance Dialysis</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>12</volume><issue>2</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>0036-5599</issn><eissn>1651-2065</eissn><abstract>The clearance for "middle molecules" measured in vitro was considerably higher for a polyacrylonitrile than for a cuprophan membrane, even when the former had been used for patients three times. Using a two pool mathematical model, an adequate correlation was found between the calculated values and those measured during RP6-Rhodial 75 dialysis (RP6). The treatment time needed for dialysis of "middle molecules" with the Gambro 13.5μ in single pass (Gambro S. P.) was four times longer than with RP6. In a long-term clinical study, when RP6 and Gambro S. P. dialysis were compared, no difference in the clinical condition of the patients was found. Clinical condition was not affected by the urea or "middle molecule" levels. The ultrafiltration tolerance was improved during hemodialysis with systems resulting in a low urea clearance.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>694443</pmid><doi>10.3109/00365597809179987</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0036-5599 |
| ispartof | Scandinavian journal of urology and nephrology, 1978-01, Vol.12 (2), p.167-174 |
| issn | 0036-5599 1651-2065 |
| language | eng |
| recordid | cdi_pubmed_primary_694443 |
| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Acrylonitrile Computers Creatinine - blood Evaluation Studies as Topic Humans Kidneys, Artificial Mathematics Membranes, Artificial Models, Theoretical Potassium - blood Renal Dialysis - methods Time Factors Toxins, Biological - blood Ultrafiltration Urea - blood Uremia - blood Uremia - therapy |
| title | Mathematical and Clinical Investigation of the RP6-Rhodial 75 System: Evaluation of High and Low Middle Molecular Clearance Dialysis |
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