Ultraviolet Light Action Spectra for Neoplastic Transformation and Lethality of Syrian Hamster Embryo Cells Correlate with Spectrum for Pyrimidine Dimer Formation in Cellular DNA

Action spectra were determined for neoplastic transformation, production of pyrimidine dimers, and lethality in Syrian hamster embryo cells. Of wavelengths between 240 and 313 nm, the most effective were 265 and 270. The relative sensitivities per quantum for transformation, pyrimidine dimer product...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1981-04, Vol.78 (4), p.2378-2382
Hauptverfasser:	Doniger, Jay, Jacobson, Elizabeth D., Krell, Kenneth, DiPaolo, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Cell Survival - radiation effects Cell Transformation, Neoplastic - radiation effects Cells Cells, Cultured Cricetinae DNA Embryonic cells Genetic mutation Irradiation Models, Biological Neoplasms, Radiation-Induced - etiology Pyrimidine Dimers Skin cancers Skin Neoplasms - etiology Spectrum Analysis Ultraviolet Rays Visible spectrum Wavelengths
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