INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA
Four groups of female Donryu rats were continuously given 400, 200, 100 or 0ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200...
Gespeichert in:
| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1983, Vol.74(3), pp.342-350 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 350 |
|---|---|
| container_issue | 3 |
| container_start_page | 342 |
| container_title | GANN Japanese Journal of Cancer Research |
| container_volume | 74 |
| creator | OGIU, Toshiaki MATSUOKA, Chiaki FURUTA, Kyoko TAKEUCHI, Masaki MAEKAWA, Akihiko NAKADATE, Masahiro ODASHIMA, Shigeyoshi |
| description | Four groups of female Donryu rats were continuously given 400, 200, 100 or 0ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0ppm groups, respectively. The predominant type of digestive tract tumor wasangiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors. |
| doi_str_mv | 10.20772/cancersci1959.74.3_342 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_6884692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>6884692</sourcerecordid><originalsourceid>FETCH-LOGICAL-j449t-cb3d7927d60d02ade66a495cd859f4689bd236847ec6e230b5051ec12d8a7d5c3</originalsourceid><addsrcrecordid>eNpVkTFPwzAQhT2AAEF_AsIDa4rjOHY8hjRtLaW2lNgSnSLXdqFVW6GkDKz8coJagbjhTrr36Q3vAfAQozFGjOEnZw8udL3bxDzlY0bGSZsQfAFuEIppRFL0cg1Gfb9Fw1DMMKNX4IpmGaEc34AvISem0EJJqKYwlzOhZqUUBdRmoeoGCgn1vIQToyalNIsfaFou8mp4KVkvDaxz3cDnJSyU1EIaZRqo6ryC-WQhpGj0oJ_NZSQa9Wz0sopkJIWuVaNMXeZ34HJtd30Yne8tMNNSF_OoUjNR5FW0JYQfI7dKPOOYeYo8wtYHSi3hqfNZyteEZnzlcUIzwoKjASdolaI0Di7GPrPMpy65Bfcn3_eP1T749r3b7G332Z6zGPTHs257Z3frbgh20_9inCAas2zAxAnb9kf7Gn512x03bhfaf320jLTJaQ2l_DFvtmvDIfkGG9F_xg</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>OGIU, Toshiaki ; MATSUOKA, Chiaki ; FURUTA, Kyoko ; TAKEUCHI, Masaki ; MAEKAWA, Akihiko ; NAKADATE, Masahiro ; ODASHIMA, Shigeyoshi</creator><creatorcontrib>OGIU, Toshiaki ; MATSUOKA, Chiaki ; FURUTA, Kyoko ; TAKEUCHI, Masaki ; MAEKAWA, Akihiko ; NAKADATE, Masahiro ; ODASHIMA, Shigeyoshi</creatorcontrib><description>Four groups of female Donryu rats were continuously given 400, 200, 100 or 0ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0ppm groups, respectively. The predominant type of digestive tract tumor wasangiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors.</description><identifier>ISSN: 0016-450X</identifier><identifier>DOI: 10.20772/cancersci1959.74.3_342</identifier><identifier>PMID: 6884692</identifier><language>eng</language><publisher>Tokyo: The Japanese Cancer Association</publisher><subject>Administration, Oral ; Angiogenic tumor ; Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens ; Chemical agents ; Chemical carcinogenesis ; Donryu rat ; Dose-Response Relationship, Drug ; Duodenal Neoplasms - chemically induced ; Duodenal Neoplasms - pathology ; Duodenal tumor ; Female ; Hemangioendothelioma - chemically induced ; Mammary Neoplasms, Experimental - chemically induced ; Medical sciences ; N-Isobutyl-N-nitrosourea ; Neoplasms, Experimental - chemically induced ; Neoplasms, Vascular Tissue - chemically induced ; Nitrosourea Compounds - toxicity ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship ; Tumors</subject><ispartof>GANN Japanese Journal of Cancer Research, 1983, Vol.74(3), pp.342-350</ispartof><rights>The Japanese Cancer Association</rights><rights>1984 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9406178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6884692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGIU, Toshiaki</creatorcontrib><creatorcontrib>MATSUOKA, Chiaki</creatorcontrib><creatorcontrib>FURUTA, Kyoko</creatorcontrib><creatorcontrib>TAKEUCHI, Masaki</creatorcontrib><creatorcontrib>MAEKAWA, Akihiko</creatorcontrib><creatorcontrib>NAKADATE, Masahiro</creatorcontrib><creatorcontrib>ODASHIMA, Shigeyoshi</creatorcontrib><title>INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA</title><title>GANN Japanese Journal of Cancer Research</title><addtitle>GANN Japanese Journal of Cancer Research</addtitle><description>Four groups of female Donryu rats were continuously given 400, 200, 100 or 0ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0ppm groups, respectively. The predominant type of digestive tract tumor wasangiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors.</description><subject>Administration, Oral</subject><subject>Angiogenic tumor</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogens</subject><subject>Chemical agents</subject><subject>Chemical carcinogenesis</subject><subject>Donryu rat</subject><subject>Dose-Response Relationship, Drug</subject><subject>Duodenal Neoplasms - chemically induced</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Duodenal tumor</subject><subject>Female</subject><subject>Hemangioendothelioma - chemically induced</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Medical sciences</subject><subject>N-Isobutyl-N-nitrosourea</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Neoplasms, Vascular Tissue - chemically induced</subject><subject>Nitrosourea Compounds - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Structure-Activity Relationship</subject><subject>Tumors</subject><issn>0016-450X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTFPwzAQhT2AAEF_AsIDa4rjOHY8hjRtLaW2lNgSnSLXdqFVW6GkDKz8coJagbjhTrr36Q3vAfAQozFGjOEnZw8udL3bxDzlY0bGSZsQfAFuEIppRFL0cg1Gfb9Fw1DMMKNX4IpmGaEc34AvISem0EJJqKYwlzOhZqUUBdRmoeoGCgn1vIQToyalNIsfaFou8mp4KVkvDaxz3cDnJSyU1EIaZRqo6ryC-WQhpGj0oJ_NZSQa9Wz0sopkJIWuVaNMXeZ34HJtd30Yne8tMNNSF_OoUjNR5FW0JYQfI7dKPOOYeYo8wtYHSi3hqfNZyteEZnzlcUIzwoKjASdolaI0Di7GPrPMpy65Bfcn3_eP1T749r3b7G332Z6zGPTHs257Z3frbgh20_9inCAas2zAxAnb9kf7Gn512x03bhfaf320jLTJaQ2l_DFvtmvDIfkGG9F_xg</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>OGIU, Toshiaki</creator><creator>MATSUOKA, Chiaki</creator><creator>FURUTA, Kyoko</creator><creator>TAKEUCHI, Masaki</creator><creator>MAEKAWA, Akihiko</creator><creator>NAKADATE, Masahiro</creator><creator>ODASHIMA, Shigeyoshi</creator><general>The Japanese Cancer Association</general><general>Japan Publications Trading</general><general>Japanese Cancer Association</general><general>Cancer Institute</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19830101</creationdate><title>INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA</title><author>OGIU, Toshiaki ; MATSUOKA, Chiaki ; FURUTA, Kyoko ; TAKEUCHI, Masaki ; MAEKAWA, Akihiko ; NAKADATE, Masahiro ; ODASHIMA, Shigeyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j449t-cb3d7927d60d02ade66a495cd859f4689bd236847ec6e230b5051ec12d8a7d5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Administration, Oral</topic><topic>Angiogenic tumor</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogens</topic><topic>Chemical agents</topic><topic>Chemical carcinogenesis</topic><topic>Donryu rat</topic><topic>Dose-Response Relationship, Drug</topic><topic>Duodenal Neoplasms - chemically induced</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Duodenal tumor</topic><topic>Female</topic><topic>Hemangioendothelioma - chemically induced</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Medical sciences</topic><topic>N-Isobutyl-N-nitrosourea</topic><topic>Neoplasms, Experimental - chemically induced</topic><topic>Neoplasms, Vascular Tissue - chemically induced</topic><topic>Nitrosourea Compounds - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Structure-Activity Relationship</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>OGIU, Toshiaki</creatorcontrib><creatorcontrib>MATSUOKA, Chiaki</creatorcontrib><creatorcontrib>FURUTA, Kyoko</creatorcontrib><creatorcontrib>TAKEUCHI, Masaki</creatorcontrib><creatorcontrib>MAEKAWA, Akihiko</creatorcontrib><creatorcontrib>NAKADATE, Masahiro</creatorcontrib><creatorcontrib>ODASHIMA, Shigeyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>GANN Japanese Journal of Cancer Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGIU, Toshiaki</au><au>MATSUOKA, Chiaki</au><au>FURUTA, Kyoko</au><au>TAKEUCHI, Masaki</au><au>MAEKAWA, Akihiko</au><au>NAKADATE, Masahiro</au><au>ODASHIMA, Shigeyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA</atitle><jtitle>GANN Japanese Journal of Cancer Research</jtitle><addtitle>GANN Japanese Journal of Cancer Research</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>74</volume><issue>3</issue><spage>342</spage><epage>350</epage><pages>342-350</pages><issn>0016-450X</issn><abstract>Four groups of female Donryu rats were continuously given 400, 200, 100 or 0ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0ppm groups, respectively. The predominant type of digestive tract tumor wasangiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors.</abstract><cop>Tokyo</cop><pub>The Japanese Cancer Association</pub><pmid>6884692</pmid><doi>10.20772/cancersci1959.74.3_342</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-450X |
| ispartof | GANN Japanese Journal of Cancer Research, 1983, Vol.74(3), pp.342-350 |
| issn | 0016-450X |
| language | eng |
| recordid | cdi_pubmed_primary_6884692 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Oral Angiogenic tumor Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens Chemical agents Chemical carcinogenesis Donryu rat Dose-Response Relationship, Drug Duodenal Neoplasms - chemically induced Duodenal Neoplasms - pathology Duodenal tumor Female Hemangioendothelioma - chemically induced Mammary Neoplasms, Experimental - chemically induced Medical sciences N-Isobutyl-N-nitrosourea Neoplasms, Experimental - chemically induced Neoplasms, Vascular Tissue - chemically induced Nitrosourea Compounds - toxicity Rats Rats, Inbred Strains Structure-Activity Relationship Tumors |
| title | INDUCTION OF ANGIOGENIC TUMORS IN THE DUODENUM OF FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF N-ISOBUTYL-N-NITROSOUREA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A21%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=INDUCTION%20OF%20ANGIOGENIC%20TUMORS%20IN%20THE%20DUODENUM%20OF%20FEMALE%20DONRYU%20RATS%20BY%20CONTINUOUS%20ORAL%20ADMINISTRATION%20OF%20N-ISOBUTYL-N-NITROSOUREA&rft.jtitle=GANN%20Japanese%20Journal%20of%20Cancer%20Research&rft.au=OGIU,%20Toshiaki&rft.date=1983-01-01&rft.volume=74&rft.issue=3&rft.spage=342&rft.epage=350&rft.pages=342-350&rft.issn=0016-450X&rft_id=info:doi/10.20772/cancersci1959.74.3_342&rft_dat=%3Cpubmed_pasca%3E6884692%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/6884692&rfr_iscdi=true |