Labeling with Indium-111 has Detrimental Effects on Human Lymphocytes: Concise Communication

When lymphocytes from human peripheral blood were labeled with In-111 oxinate, several of their properties appeared to be affected. The spontaneous release of the radionuclide was found to be relatively high. Labeled lymphocytes showed a decreased proliferative capacity, dependent on the dose of the...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1983-07, Vol.24 (7), p.615
Hauptverfasser:	ten Berge, R. J. M, Natarajan, A. T, Hardeman, M. R, van Royen, E. A, Schellekens, P. Th. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Division - radiation effects Chromosome Aberrations Dose-Response Relationship, Radiation Humans Indium - adverse effects Lymphocytes - cytology Lymphocytes - radiation effects Radioisotopes - adverse effects
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container_title	The Journal of nuclear medicine (1978)
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creator	ten Berge, R. J. M Natarajan, A. T Hardeman, M. R van Royen, E. A Schellekens, P. Th. A
description	When lymphocytes from human peripheral blood were labeled with In-111 oxinate, several of their properties appeared to be affected. The spontaneous release of the radionuclide was found to be relatively high. Labeled lymphocytes showed a decreased proliferative capacity, dependent on the dose of the label. Cytogenetic studies revealed that In-111 oxinate induces severe chromosomal aberrations. These results emphasize the need for great caution in the use of the In-111 label for studies on lymphocyte traffic in humans.
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These results emphasize the need for great caution in the use of the In-111 label for studies on lymphocyte traffic in humans.</description><subject>Cell Division - radiation effects</subject><subject>Chromosome Aberrations</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Humans</subject><subject>Indium - adverse effects</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - radiation effects</subject><subject>Radioisotopes - adverse effects</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkEFLwzAcxYMoc04_gpCTt0L-SZNm3mRONyh40ZtQ0iRdM5p0NCmj397KdnqH3-Px3rtBS-CMZ1yI4hYtCQjIOCf8Hj3EeCSECCnlAi2EFDmDfIl-S1XbzoUDPrvU4n0wbvQZAOBWRfxu0-C8DUl1eNs0VqeI-4B3o1cBl5M_tb2eko2veNMH7aKd1fsxOK2S68MjumtUF-3TVVfo52P7vdll5dfnfvNWZi1wmjItqGG01uvGiLqAnGgCSlLFGRRrThgFU3OjRU5BrfOGU6ak5lRKyGtDbcFW6PmSexprb011mkurYaquK2f-cuGtO7RnN9gqjLqzavg3H4OneVVUYj7uDyorW_k</recordid><startdate>198307</startdate><enddate>198307</enddate><creator>ten Berge, R. 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These results emphasize the need for great caution in the use of the In-111 label for studies on lymphocyte traffic in humans.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>6864314</pmid></addata></record>
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Cell Division - radiation effects Chromosome Aberrations Dose-Response Relationship, Radiation Humans Indium - adverse effects Lymphocytes - cytology Lymphocytes - radiation effects Radioisotopes - adverse effects
title	Labeling with Indium-111 has Detrimental Effects on Human Lymphocytes: Concise Communication
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