Post-anesthetic hepatitis. The role of halothane and antimitotic combinations
A 12 year old boy with Burkitt's lymphoma developed severe hepatitis with hepatomegaly, subclinical jaundice, and a small rise in body temperature, associated with an important rise in SGPT and fall in prothrombin titres, 6 days after anticancer chemotherapy and 24 hours after halothane anaesth...
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| Veröffentlicht in: | Annales françaises d'anesthésie et de réanimation 1984, Vol.3 (3), p.212 |
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| container_title | Annales françaises d'anesthésie et de réanimation |
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| creator | Gounot, R Perret-Poulat, H Métafiot, H Pouyau, G Freycon, F Cottier, M Ollagnier, M |
| description | A 12 year old boy with Burkitt's lymphoma developed severe hepatitis with hepatomegaly, subclinical jaundice, and a small rise in body temperature, associated with an important rise in SGPT and fall in prothrombin titres, 6 days after anticancer chemotherapy and 24 hours after halothane anaesthesia. Hepatitis A and B serology remained negative. This hepatic failure explained perhaps the unusually severe vincristine toxicity which gave rise to a polyneuritis with important sequelae. The association of halothane hepatitis with antimitotic drugs appeared particularly dangerous, and halothane should probably be avoided in all patients been given or about to be given anticancer chemotherapy. |
| format | Article |
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The role of halothane and antimitotic combinations</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Gounot, R ; Perret-Poulat, H ; Métafiot, H ; Pouyau, G ; Freycon, F ; Cottier, M ; Ollagnier, M</creator><creatorcontrib>Gounot, R ; Perret-Poulat, H ; Métafiot, H ; Pouyau, G ; Freycon, F ; Cottier, M ; Ollagnier, M</creatorcontrib><description>A 12 year old boy with Burkitt's lymphoma developed severe hepatitis with hepatomegaly, subclinical jaundice, and a small rise in body temperature, associated with an important rise in SGPT and fall in prothrombin titres, 6 days after anticancer chemotherapy and 24 hours after halothane anaesthesia. Hepatitis A and B serology remained negative. This hepatic failure explained perhaps the unusually severe vincristine toxicity which gave rise to a polyneuritis with important sequelae. The association of halothane hepatitis with antimitotic drugs appeared particularly dangerous, and halothane should probably be avoided in all patients been given or about to be given anticancer chemotherapy.</description><identifier>ISSN: 0750-7658</identifier><identifier>PMID: 6742542</identifier><language>fre</language><publisher>France</publisher><subject>Anesthesia, Inhalation ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Burkitt Lymphoma - drug therapy ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - pathology ; Child ; Drug Therapy, Combination ; Halothane - adverse effects ; Humans ; Male</subject><ispartof>Annales françaises d'anesthésie et de réanimation, 1984, Vol.3 (3), p.212</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6742542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gounot, R</creatorcontrib><creatorcontrib>Perret-Poulat, H</creatorcontrib><creatorcontrib>Métafiot, H</creatorcontrib><creatorcontrib>Pouyau, G</creatorcontrib><creatorcontrib>Freycon, F</creatorcontrib><creatorcontrib>Cottier, M</creatorcontrib><creatorcontrib>Ollagnier, M</creatorcontrib><title>Post-anesthetic hepatitis. The role of halothane and antimitotic combinations</title><title>Annales françaises d'anesthésie et de réanimation</title><addtitle>Ann Fr Anesth Reanim</addtitle><description>A 12 year old boy with Burkitt's lymphoma developed severe hepatitis with hepatomegaly, subclinical jaundice, and a small rise in body temperature, associated with an important rise in SGPT and fall in prothrombin titres, 6 days after anticancer chemotherapy and 24 hours after halothane anaesthesia. Hepatitis A and B serology remained negative. This hepatic failure explained perhaps the unusually severe vincristine toxicity which gave rise to a polyneuritis with important sequelae. The association of halothane hepatitis with antimitotic drugs appeared particularly dangerous, and halothane should probably be avoided in all patients been given or about to be given anticancer chemotherapy.</description><subject>Anesthesia, Inhalation</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Burkitt Lymphoma - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Child</subject><subject>Drug Therapy, Combination</subject><subject>Halothane - adverse effects</subject><subject>Humans</subject><subject>Male</subject><issn>0750-7658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjb0OgjAUhTtoEH8ewaQvgKlAwd1oXEwc2EmBS3oN7SX0Ovj2YuLucHKG8305CxGrUqukLPRpJdYhPJVSOsuPkYiKMk91nsbi_qDAifEQ2AJjKy2MhpExHGRlQU40gKReWjMQ25mTxndzGB0yfYWWXIN-dsiHrVj2Zgiw-_VG7K-X6nxLxlfjoKvHCZ2Z3vXvPvu3fwCIqTsX</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Gounot, R</creator><creator>Perret-Poulat, H</creator><creator>Métafiot, H</creator><creator>Pouyau, G</creator><creator>Freycon, F</creator><creator>Cottier, M</creator><creator>Ollagnier, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1984</creationdate><title>Post-anesthetic hepatitis. 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| fulltext | fulltext |
| identifier | ISSN: 0750-7658 |
| ispartof | Annales françaises d'anesthésie et de réanimation, 1984, Vol.3 (3), p.212 |
| issn | 0750-7658 |
| language | fre |
| recordid | cdi_pubmed_primary_6742542 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anesthesia, Inhalation Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Burkitt Lymphoma - drug therapy Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Child Drug Therapy, Combination Halothane - adverse effects Humans Male |
| title | Post-anesthetic hepatitis. The role of halothane and antimitotic combinations |
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