Systemic and Regional Hemodynamics in Normotensive and Spontaneously Hypertensive Rats after Slow-Channel Calcium Blocker Nitrendipine
To determine the effects of the recently synthesized slow channel calcium blocker nitrendipine on systemic and regional hemodynamics, mean arterial pressure, heart rate, cardiac index and organ blood flow distribution were measured with the combined radioactive reference sample and microsphere techn...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 1984, Vol.A6 (5), p.979-991 |
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| container_title | Clinical and experimental hypertension (1993) |
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| creator | Sesoko, Shoji Pegram, Barbara L. Frohlich, Edward D. |
| description | To determine the effects of the recently synthesized slow channel calcium blocker nitrendipine on systemic and regional hemodynamics, mean arterial pressure, heart rate, cardiac index and organ blood flow distribution were measured with the combined radioactive reference sample and microsphere techniques before and one hour after its oral administration (1 mg or 10 mg/kg). Twenty-week-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) conscious male rats were studied. At the 10 mg dose, nitrendipine exerted a hypotensive effect within 15 minutes, and this effect persisted throughout the study. After one hour, mean arterial pressure fell by 14 percent of pretreatment levels in WKY controls; it fell by 25 percent in SHR (p < 0.001). This action was mediated by a fall in total peripheral resistance index (p < 0.01) that was nonuniformly distributed to the organ circulations since blood flow was maintained or increased to brain, heart, kidneys, lungs, and adrenals, but decreased to skin. No change in cardiac index was observed. |
| doi_str_mv | 10.3109/10641968409044051 |
| format | Article |
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Twenty-week-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) conscious male rats were studied. At the 10 mg dose, nitrendipine exerted a hypotensive effect within 15 minutes, and this effect persisted throughout the study. After one hour, mean arterial pressure fell by 14 percent of pretreatment levels in WKY controls; it fell by 25 percent in SHR (p < 0.001). This action was mediated by a fall in total peripheral resistance index (p < 0.01) that was nonuniformly distributed to the organ circulations since blood flow was maintained or increased to brain, heart, kidneys, lungs, and adrenals, but decreased to skin. No change in cardiac index was observed.</description><identifier>ISSN: 1064-1963</identifier><identifier>ISSN: 0730-0077</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.3109/10641968409044051</identifier><identifier>PMID: 6733943</identifier><identifier>CODEN: CEHADM</identifier><language>eng</language><publisher>Basel: Informa UK Ltd</publisher><subject>Animals ; Antihypertensive agents ; Antihypertensive Drugs ; Biological and medical sciences ; Blood Pressure - drug effects ; Calcium Channel Blockers - therapeutic use ; Cardiac Output - drug effects ; Cardiovascular system ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Hypertension - drug therapy ; Male ; Medical sciences ; Nifedipine - analogs & derivatives ; Nifedipine - therapeutic use ; Nitrendipine ; Organ Blood Flows ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Regional Blood Flow - drug effects ; SHR ; Slow-Channel Calcium Blocker ; Systemic and Regional Hemodynamics ; Time Factors ; Vascular Resistance - drug effects</subject><ispartof>Clinical and experimental hypertension (1993), 1984, Vol.A6 (5), p.979-991</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-110131374b8c039aa14f968d7121cb8db3d40d05178debe5d19df014938cebde3</citedby><cites>FETCH-LOGICAL-c430t-110131374b8c039aa14f968d7121cb8db3d40d05178debe5d19df014938cebde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10641968409044051$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10641968409044051$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9109374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6733943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sesoko, Shoji</creatorcontrib><creatorcontrib>Pegram, Barbara L.</creatorcontrib><creatorcontrib>Frohlich, Edward D.</creatorcontrib><title>Systemic and Regional Hemodynamics in Normotensive and Spontaneously Hypertensive Rats after Slow-Channel Calcium Blocker Nitrendipine</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens A</addtitle><description>To determine the effects of the recently synthesized slow channel calcium blocker nitrendipine on systemic and regional hemodynamics, mean arterial pressure, heart rate, cardiac index and organ blood flow distribution were measured with the combined radioactive reference sample and microsphere techniques before and one hour after its oral administration (1 mg or 10 mg/kg). Twenty-week-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) conscious male rats were studied. At the 10 mg dose, nitrendipine exerted a hypotensive effect within 15 minutes, and this effect persisted throughout the study. After one hour, mean arterial pressure fell by 14 percent of pretreatment levels in WKY controls; it fell by 25 percent in SHR (p < 0.001). This action was mediated by a fall in total peripheral resistance index (p < 0.01) that was nonuniformly distributed to the organ circulations since blood flow was maintained or increased to brain, heart, kidneys, lungs, and adrenals, but decreased to skin. No change in cardiac index was observed.</description><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Drugs</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiovascular system</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Hypertension - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nifedipine - analogs & derivatives</subject><subject>Nifedipine - therapeutic use</subject><subject>Nitrendipine</subject><subject>Organ Blood Flows</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Regional Blood Flow - drug effects</subject><subject>SHR</subject><subject>Slow-Channel Calcium Blocker</subject><subject>Systemic and Regional Hemodynamics</subject><subject>Time Factors</subject><subject>Vascular Resistance - drug effects</subject><issn>1064-1963</issn><issn>0730-0077</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhSMEKqXwAzgg-YC4BTxrJ5sILrACFqkqUhfO0cSesC6OHWyHKn-A341ht5UQUk-29L43nvdcFE-BvxTA21fAawlt3Ujecil5BfeKU6hWVVlzXt_P96yXGRAPi0cxXnEOsq6ak-KkXgvRSnFa_NotMdFoFEOn2SV9M96hZVsavV4cZiEy49iFD6NP5KL5SX_J3eRdQkd-jnZh22WicCNfYooMh0SB7ay_Ljd7dI4s26BVZh7ZO-vV9yxemBTIaTMZR4-LBwPaSE-O51nx9cP7L5ttef7546fN2_NSScFTCcBBgFjLvlFctIgghxxfr2EFqm90L7TkOvewbjT1VGlo9ZBDt6JR1GsSZ8WLw9wp-B8zxdSNJiqy9hClayA_sZIyg3AAVfAxBhq6KZgRw9IB7_503_3XffY8Ow6f-5H0reNYdtafH3WMCu0Q0CkTb7E2T83RMvbmgBk35Nrx2geru4SL9eHGI-7a4vU_9j2hTXuFgborP4f8u_GODL8BxIezPA</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Sesoko, Shoji</creator><creator>Pegram, Barbara L.</creator><creator>Frohlich, Edward D.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Systemic and Regional Hemodynamics in Normotensive and Spontaneously Hypertensive Rats after Slow-Channel Calcium Blocker Nitrendipine</title><author>Sesoko, Shoji ; Pegram, Barbara L. ; Frohlich, Edward D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-110131374b8c039aa14f968d7121cb8db3d40d05178debe5d19df014938cebde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Drugs</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiovascular system</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Hypertension - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nifedipine - analogs & derivatives</topic><topic>Nifedipine - therapeutic use</topic><topic>Nitrendipine</topic><topic>Organ Blood Flows</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Regional Blood Flow - drug effects</topic><topic>SHR</topic><topic>Slow-Channel Calcium Blocker</topic><topic>Systemic and Regional Hemodynamics</topic><topic>Time Factors</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sesoko, Shoji</creatorcontrib><creatorcontrib>Pegram, Barbara L.</creatorcontrib><creatorcontrib>Frohlich, Edward D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sesoko, Shoji</au><au>Pegram, Barbara L.</au><au>Frohlich, Edward D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic and Regional Hemodynamics in Normotensive and Spontaneously Hypertensive Rats after Slow-Channel Calcium Blocker Nitrendipine</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens A</addtitle><date>1984</date><risdate>1984</risdate><volume>A6</volume><issue>5</issue><spage>979</spage><epage>991</epage><pages>979-991</pages><issn>1064-1963</issn><issn>0730-0077</issn><eissn>1525-6006</eissn><coden>CEHADM</coden><abstract>To determine the effects of the recently synthesized slow channel calcium blocker nitrendipine on systemic and regional hemodynamics, mean arterial pressure, heart rate, cardiac index and organ blood flow distribution were measured with the combined radioactive reference sample and microsphere techniques before and one hour after its oral administration (1 mg or 10 mg/kg). Twenty-week-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) conscious male rats were studied. At the 10 mg dose, nitrendipine exerted a hypotensive effect within 15 minutes, and this effect persisted throughout the study. After one hour, mean arterial pressure fell by 14 percent of pretreatment levels in WKY controls; it fell by 25 percent in SHR (p < 0.001). This action was mediated by a fall in total peripheral resistance index (p < 0.01) that was nonuniformly distributed to the organ circulations since blood flow was maintained or increased to brain, heart, kidneys, lungs, and adrenals, but decreased to skin. No change in cardiac index was observed.</abstract><cop>Basel</cop><cop>Hong Kong</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>6733943</pmid><doi>10.3109/10641968409044051</doi><tpages>13</tpages></addata></record> |
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| ispartof | Clinical and experimental hypertension (1993), 1984, Vol.A6 (5), p.979-991 |
| issn | 1064-1963 0730-0077 1525-6006 |
| language | eng |
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| source | MEDLINE; Access via Taylor & Francis |
| subjects | Animals Antihypertensive agents Antihypertensive Drugs Biological and medical sciences Blood Pressure - drug effects Calcium Channel Blockers - therapeutic use Cardiac Output - drug effects Cardiovascular system Heart Rate - drug effects Hemodynamics - drug effects Hypertension - drug therapy Male Medical sciences Nifedipine - analogs & derivatives Nifedipine - therapeutic use Nitrendipine Organ Blood Flows Pharmacology. Drug treatments Rats Rats, Inbred Strains Regional Blood Flow - drug effects SHR Slow-Channel Calcium Blocker Systemic and Regional Hemodynamics Time Factors Vascular Resistance - drug effects |
| title | Systemic and Regional Hemodynamics in Normotensive and Spontaneously Hypertensive Rats after Slow-Channel Calcium Blocker Nitrendipine |
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