Formation of O6-methylguanine in regenerating rat liver by N-nitrosomethylbenzylamine is not sufficient for initiation of preneoplastic foci

The DNA methylating activities of N-nitrosodimethylamine (NDMA), an initiator of hepatic γ-glutamyltranspeptidase-positive foci, and N-nitrosomethylbenzylamine (NMBzA), which does not initiate, were studied in regenerating rat liver. Equimolar doses of 14C-labelled NDMA and NMBzA (33.5 μmol/kg) were...

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Veröffentlicht in:	Carcinogenesis (New York) 1984-04, Vol.5 (4), p.541-542
Hauptverfasser:	Silinskas, K. Charles, Zucker, Peter F., Labuc, George E., Archer, Michael C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Dimethylnitrosamine - analogs & derivatives Dimethylnitrosamine - metabolism Dimethylnitrosamine - toxicity Guanine - analogs & derivatives Guanine - biosynthesis Kinetics Liver - drug effects Liver - metabolism Liver Regeneration Male Medical sciences Rats Rats, Inbred Strains Tumors
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