Croton Oil Enhancement of Skin Tumor Initiation by N-Methyl-N′-Nitro-N-Nitrosoguanidine: Possible Role of DNA Replication

Summary An application of 0.5% croton oil at times from 6 hr before until 24) hr after initiation with 4 μmoles MNNG led to a threefold increase in papilloma yield and a substantial shortening of the latent period in two-stage tumor induction experiments in mouse skin. Since DNA replication was not...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1978-05, Vol.158 (1), p.1-4
Hauptverfasser:	Hennings, Henry, Michael, Delores, Patterson, Elroy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Croton Oil - administration & dosage Croton Oil - toxicity DNA - biosynthesis DNA Repair - drug effects DNA Replication - drug effects Drug Synergism Female Methylnitronitrosoguanidine - administration & dosage Mice Neoplasms, Experimental - chemically induced Papilloma - chemically induced Skin - drug effects Skin - metabolism Skin Neoplasms - chemically induced Time Factors
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