Toward an Analogue of Alcoholism in Mice: Scale Factors in the Model
Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1984-06, Vol.81 (11), p.3543-3546 |
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| container_end_page | 3546 |
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| container_issue | 11 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Dole, Vincent P. Gentry, R. Thomas |
| description | Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since the drinking lacks serious toxic effects and the intoxication occurs only as transient episodes in association with homeostatic consumption of fluid and food. It is suggested that continuous monitoring of intake and estimation of the concentration of alcohol in blood, which are now technically feasible, will permit distinction between alcoholic-type drinking and a simple licking for the flavor of alcohol in beverage concentration. |
| doi_str_mv | 10.1073/pnas.81.11.3543 |
| format | Article |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1984-06, Vol.81 (11), p.3543-3546 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alcohol drinking Alcoholic beverages Alcoholism Alcoholism - metabolism Alcohols Animals Blood Blood plasma Body water Body Weight Disease Models, Animal Ethanol - blood Ethanol - metabolism Humans Male Metabolic Clearance Rate Metabolism Mice Mice, Inbred C57BL Pharmacology Tissue Distribution |
| title | Toward an Analogue of Alcoholism in Mice: Scale Factors in the Model |
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