COMPARISON OF I.V. GLYCOPYRROLATE AND ATROPINE IN THE PREVENTION OF BRADYCARDIA AND ARRHYTHMIAS FOLLOWING REPEATED DOSES OF SUXAMETHONIUM IN CHILDREN
The effectiveness of administration of grycopyrrolate 5 and 10 μg kg−1 and atropine 10 and 20 μg kg−1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for compa...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1984-09, Vol.56 (9), p.981-985 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | GREEN, D.W. BRISTOW, A.S.E. FISHER, M. |
| description | The effectiveness of administration of grycopyrrolate 5 and 10 μg kg−1 and atropine 10 and 20 μg kg−1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comparison with the lower dose range of grycopyrrolate and atropine. A frequency of bradycardia of 50% was noted in the control group, but this was not significantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min−1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 mg kg−1 or atropine 20 μg kg−1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suzamethonium is anticipated |
| doi_str_mv | 10.1093/bja/56.9.981 |
| format | Article |
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Bradycardia (defined as a decrease in heart rate to less than 50 beat min−1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 mg kg−1 or atropine 20 μg kg−1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suzamethonium is anticipated</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/56.9.981</identifier><identifier>PMID: 6466532</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia ; Anesthesia depending on patient's condition ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - prevention & control ; Atropine ; Biological and medical sciences ; Bradycardia - chemically induced ; Bradycardia - prevention & control ; Child ; Double-Blind Method ; Female ; Glycopyrrolate ; Heart Rate - drug effects ; Humans ; Intraoperative Complications ; Male ; Medical sciences ; Preanesthetic Medication ; Pyrrolidines ; Random Allocation ; Succinylcholine - adverse effects</subject><ispartof>British journal of anaesthesia : BJA, 1984-09, Vol.56 (9), p.981-985</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8857291$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6466532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GREEN, D.W.</creatorcontrib><creatorcontrib>BRISTOW, A.S.E.</creatorcontrib><creatorcontrib>FISHER, M.</creatorcontrib><title>COMPARISON OF I.V. GLYCOPYRROLATE AND ATROPINE IN THE PREVENTION OF BRADYCARDIA AND ARRHYTHMIAS FOLLOWING REPEATED DOSES OF SUXAMETHONIUM IN CHILDREN</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>The effectiveness of administration of grycopyrrolate 5 and 10 μg kg−1 and atropine 10 and 20 μg kg−1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comparison with the lower dose range of grycopyrrolate and atropine. A frequency of bradycardia of 50% was noted in the control group, but this was not significantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min−1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 mg kg−1 or atropine 20 μg kg−1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suzamethonium is anticipated</description><subject>Anesthesia</subject><subject>Anesthesia depending on patient's condition</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - prevention & control</subject><subject>Atropine</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - chemically induced</subject><subject>Bradycardia - prevention & control</subject><subject>Child</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Glycopyrrolate</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Intraoperative Complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Preanesthetic Medication</subject><subject>Pyrrolidines</subject><subject>Random Allocation</subject><subject>Succinylcholine - adverse effects</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUuPmzAUha2q1TSddtdtJS-6JWPz8GNJwQmWACNDppNuLANGYjovQVq1P6T_t0REs7qL850j3XMA-IzRFiMe3LT39iYiW77lDL8BGxxS7BFK8VuwQQhRD3Hsvwcf5vkeIUx9Hl2BKxISEgX-BvxLVFHFWtaqhGoH5fZ2C_f5MVHVUWuVx42AcZnCuNGqkqWAsoRNJmClxa0oG7m6vuk4PSaxTmW80lpnxyYrZFzDncpz9V2We6hFJZa8FKaqFvXZVx_u4kI0mSrloThHJ5nMUy3Kj-DdYB9m9-lyr8FhJ5ok83K1l0mcey7w0cljPY5cj3pm24BjR4mPW-x3ERkivw27nqNwaLmlFjGGB8Yxbp2jjFJme0SjNrgGX9bcl1_to-vNyzQ-2umvudSz6F8vup07-zBM9qkb51eMsWjpEy-Yt2LjfHJ_XmU7_TSEBjQy2d0PE4ZBUVK9N-HCk5V3y2-_RzeZuRvdU-f6cXLdyfTPo8HInNc1y7omIoabZd3gP9pJiR0</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>GREEN, D.W.</creator><creator>BRISTOW, A.S.E.</creator><creator>FISHER, M.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198409</creationdate><title>COMPARISON OF I.V. GLYCOPYRROLATE AND ATROPINE IN THE PREVENTION OF BRADYCARDIA AND ARRHYTHMIAS FOLLOWING REPEATED DOSES OF SUXAMETHONIUM IN CHILDREN</title><author>GREEN, D.W. ; BRISTOW, A.S.E. ; FISHER, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e320t-8d15ed0d8ab391e7621b12c56f52b4cd904fb9a7a0881f8911bee78778ad075b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on patient's condition</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arrhythmias, Cardiac - prevention & control</topic><topic>Atropine</topic><topic>Biological and medical sciences</topic><topic>Bradycardia - chemically induced</topic><topic>Bradycardia - prevention & control</topic><topic>Child</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Glycopyrrolate</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Intraoperative Complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Preanesthetic Medication</topic><topic>Pyrrolidines</topic><topic>Random Allocation</topic><topic>Succinylcholine - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GREEN, D.W.</creatorcontrib><creatorcontrib>BRISTOW, A.S.E.</creatorcontrib><creatorcontrib>FISHER, M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GREEN, D.W.</au><au>BRISTOW, A.S.E.</au><au>FISHER, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPARISON OF I.V. GLYCOPYRROLATE AND ATROPINE IN THE PREVENTION OF BRADYCARDIA AND ARRHYTHMIAS FOLLOWING REPEATED DOSES OF SUXAMETHONIUM IN CHILDREN</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1984-09</date><risdate>1984</risdate><volume>56</volume><issue>9</issue><spage>981</spage><epage>985</epage><pages>981-985</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>The effectiveness of administration of grycopyrrolate 5 and 10 μg kg−1 and atropine 10 and 20 μg kg−1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comparison with the lower dose range of grycopyrrolate and atropine. A frequency of bradycardia of 50% was noted in the control group, but this was not significantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min−1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 mg kg−1 or atropine 20 μg kg−1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suzamethonium is anticipated</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>6466532</pmid><doi>10.1093/bja/56.9.981</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1984-09, Vol.56 (9), p.981-985 |
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| language | eng |
| recordid | cdi_pubmed_primary_6466532 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Anesthesia Anesthesia depending on patient's condition Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - prevention & control Atropine Biological and medical sciences Bradycardia - chemically induced Bradycardia - prevention & control Child Double-Blind Method Female Glycopyrrolate Heart Rate - drug effects Humans Intraoperative Complications Male Medical sciences Preanesthetic Medication Pyrrolidines Random Allocation Succinylcholine - adverse effects |
| title | COMPARISON OF I.V. GLYCOPYRROLATE AND ATROPINE IN THE PREVENTION OF BRADYCARDIA AND ARRHYTHMIAS FOLLOWING REPEATED DOSES OF SUXAMETHONIUM IN CHILDREN |
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