Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection

The effectiveness of the clinically useful fluoropyrimidines in the treatment of human cancer is often limited by the development of resistance to the drugs by the tumor. In order to systematically study the mechanisms of resistance to 5-fluorouracil and its nucleoside derivatives, several cell line...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1982-03, Vol.42 (3), p.956
Hauptverfasser:	Mulkins, M A, Heidelberger, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Cell Line Cell Separation Cytological Techniques Drug Resistance Floxuridine - pharmacology Fluorouracil - pharmacology Leukemia L1210 Leukemia P388 Leukemia, Experimental - drug therapy Leukemia, Experimental - metabolism Leukemia, Experimental - ultrastructure Mice Mutation Phenotype Selection, Genetic Uridine - analogs & derivatives Uridine - pharmacology
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