Potentiation of the effect of steroid hormones (progesterone and testosterone) inducing the reinitiation of meiosis in Xenopus oocytes in vitro, by inhibitors of phosphatase activity
The induction of meiosis reinitiation by steroid hormones (progesterone and testosterone) in Xenopus laevis oocytes was studied in vitro in presence of inhibitors of phosphatase activity such as beta-glycerophosphate, considered as a competitive inhibitor, and the two ions, Zn++ and MoO--4. Kinetics...
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| Veröffentlicht in: | Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie Série III, Sciences de la vie, 1984, Vol.299 (4), p.89 |
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| container_title | Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie |
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| creator | Le Goascogne, C Sananès, N Gouézou, M Baulieu, E E |
| description | The induction of meiosis reinitiation by steroid hormones (progesterone and testosterone) in Xenopus laevis oocytes was studied in vitro in presence of inhibitors of phosphatase activity such as beta-glycerophosphate, considered as a competitive inhibitor, and the two ions, Zn++ and MoO--4. Kinetics of the germinal vesicle breakdown indicating the reinitiation of meiosis, have shown that while these phosphatase inhibitors were not active by themselves under the present experimental conditions, they enhanced the process elicited by progesterone or testosterone. |
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Kinetics of the germinal vesicle breakdown indicating the reinitiation of meiosis, have shown that while these phosphatase inhibitors were not active by themselves under the present experimental conditions, they enhanced the process elicited by progesterone or testosterone.</description><subject>Alkaline Phosphatase - antagonists & inhibitors</subject><subject>Animals</subject><subject>Chlorides</subject><subject>Drug Synergism</subject><subject>Female</subject><subject>Glycerophosphates - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Meiosis - drug effects</subject><subject>Molybdenum - pharmacology</subject><subject>Oocytes - cytology</subject><subject>Oocytes - drug effects</subject><subject>Progesterone - pharmacology</subject><subject>Testosterone - pharmacology</subject><subject>Xenopus laevis</subject><subject>Zinc - pharmacology</subject><subject>Zinc Compounds</subject><issn>0764-4469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLxDAUhbNQxnH0JwhZKlhIm9d0KYMvGNDFLNwNaR7TiM0tSSr0j_n7bMdZuLqcw7nf5dwztCRSsIIxUV-gy5Q-CSGslGKBFoJRKSq6RD_vkG3IXmUPAYPDubXYOmd1nlXKNoI3uIXYQbAJ3_YRDvZoB4tVMDhPCk7GHfbBDNqHw5ETrQ_-H7uzHpJPUwh_2AD9kDCAHifCbH37HOEeN-MkWt_4DDHNW30LqW9VVmk6qLOfcuMVOnfqK9nr01yh3dPjbvNSbN-eXzcP26LnlBZca0dKyes1ExWppHROCyroXI9pw-tSVKWpFTNGljU1DVcNF2uz5pUrTUPoCt38Yfuh6azZ99F3Ko770_voL2WmcM8</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Le Goascogne, C</creator><creator>Sananès, N</creator><creator>Gouézou, M</creator><creator>Baulieu, E E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1984</creationdate><title>Potentiation of the effect of steroid hormones (progesterone and testosterone) inducing the reinitiation of meiosis in Xenopus oocytes in vitro, by inhibitors of phosphatase activity</title><author>Le Goascogne, C ; Sananès, N ; Gouézou, M ; Baulieu, E E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p533-5ccf0175984620277ffc6363ffec4cd591621d9a4dd7193db5ab568d852f1db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>1984</creationdate><topic>Alkaline Phosphatase - antagonists & inhibitors</topic><topic>Animals</topic><topic>Chlorides</topic><topic>Drug Synergism</topic><topic>Female</topic><topic>Glycerophosphates - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Meiosis - drug effects</topic><topic>Molybdenum - pharmacology</topic><topic>Oocytes - cytology</topic><topic>Oocytes - drug effects</topic><topic>Progesterone - pharmacology</topic><topic>Testosterone - pharmacology</topic><topic>Xenopus laevis</topic><topic>Zinc - pharmacology</topic><topic>Zinc Compounds</topic><toplevel>online_resources</toplevel><creatorcontrib>Le Goascogne, C</creatorcontrib><creatorcontrib>Sananès, N</creatorcontrib><creatorcontrib>Gouézou, M</creatorcontrib><creatorcontrib>Baulieu, E E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Goascogne, C</au><au>Sananès, N</au><au>Gouézou, M</au><au>Baulieu, E E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentiation of the effect of steroid hormones (progesterone and testosterone) inducing the reinitiation of meiosis in Xenopus oocytes in vitro, by inhibitors of phosphatase activity</atitle><jtitle>Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie</jtitle><addtitle>C R Acad Sci III</addtitle><date>1984</date><risdate>1984</risdate><volume>299</volume><issue>4</issue><spage>89</spage><pages>89-</pages><issn>0764-4469</issn><abstract>The induction of meiosis reinitiation by steroid hormones (progesterone and testosterone) in Xenopus laevis oocytes was studied in vitro in presence of inhibitors of phosphatase activity such as beta-glycerophosphate, considered as a competitive inhibitor, and the two ions, Zn++ and MoO--4. Kinetics of the germinal vesicle breakdown indicating the reinitiation of meiosis, have shown that while these phosphatase inhibitors were not active by themselves under the present experimental conditions, they enhanced the process elicited by progesterone or testosterone.</abstract><cop>France</cop><pmid>6437623</pmid></addata></record> |
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| identifier | ISSN: 0764-4469 |
| ispartof | Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie, 1984, Vol.299 (4), p.89 |
| issn | 0764-4469 |
| language | fre |
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| source | MEDLINE; Gallica Periodicals |
| subjects | Alkaline Phosphatase - antagonists & inhibitors Animals Chlorides Drug Synergism Female Glycerophosphates - pharmacology In Vitro Techniques Meiosis - drug effects Molybdenum - pharmacology Oocytes - cytology Oocytes - drug effects Progesterone - pharmacology Testosterone - pharmacology Xenopus laevis Zinc - pharmacology Zinc Compounds |
| title | Potentiation of the effect of steroid hormones (progesterone and testosterone) inducing the reinitiation of meiosis in Xenopus oocytes in vitro, by inhibitors of phosphatase activity |
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