Neonatal 6-Hydroxydopamine Treatment and the Development of Renal Hypertension in the Rat
The onset and development of 2 kidney-2 clip renal hypertension was studied in chronically sympathectomized rats treated with 6-hydroxy-dopamine (6-OHDA) immediately after birth and with adrenal demedullation performed at the time of clipping. Blood pressure (BP) was lower in 6-OHDA treated animals...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 1984, Vol.A6 (5), p.1011-1026 |
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| container_title | Clinical and experimental hypertension (1993) |
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| creator | Kurnjek, María Luisa Basso, Nidia Taquini, Alberto C. |
| description | The onset and development of 2 kidney-2 clip renal hypertension was studied in chronically sympathectomized rats treated with 6-hydroxy-dopamine (6-OHDA) immediately after birth and with adrenal demedullation performed at the time of clipping. Blood pressure (BP) was lower in 6-OHDA treated animals than in untreated controls and the rate of hypertension development was similar in both groups. Urinary excretion of norepinephrine (NE) was significantly decreased during the 15th week and normal by the end of the 20th week. The cardiac NE content reached negligible levels while the mesenteric arteries retained 50% of its content. In the central nervous system (CNS) the 6-OHDA treatment induced a significant increase in NE concentration in the brain stem and medulla oblongata and a significant decrease in cerebellum. Hypertension produced a significant decrease in NE content in the brain stem while 6-OHDA treatment in hypertensive rats resulted in a generalized NE depletion in all the CNS areas. Results have shown that 6-OHDA treatment does not produce a complete and generally distributed sympathectomy; treatment reduces the level of BP but does not change the slope in BP increase. |
| doi_str_mv | 10.3109/10641968409044053 |
| format | Article |
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Blood pressure (BP) was lower in 6-OHDA treated animals than in untreated controls and the rate of hypertension development was similar in both groups. Urinary excretion of norepinephrine (NE) was significantly decreased during the 15th week and normal by the end of the 20th week. The cardiac NE content reached negligible levels while the mesenteric arteries retained 50% of its content. In the central nervous system (CNS) the 6-OHDA treatment induced a significant increase in NE concentration in the brain stem and medulla oblongata and a significant decrease in cerebellum. Hypertension produced a significant decrease in NE content in the brain stem while 6-OHDA treatment in hypertensive rats resulted in a generalized NE depletion in all the CNS areas. Results have shown that 6-OHDA treatment does not produce a complete and generally distributed sympathectomy; treatment reduces the level of BP but does not change the slope in BP increase.</description><identifier>ISSN: 1064-1963</identifier><identifier>ISSN: 0730-0077</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.3109/10641968409044053</identifier><identifier>PMID: 6428783</identifier><identifier>CODEN: CEHADM</identifier><language>eng</language><publisher>Basel: Informa UK Ltd</publisher><subject>Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Brain - metabolism ; Cardiology. Vascular system ; Catecholamines ; Epinephrine ; Experimental diseases ; Hydroxydopamines ; Hypertension, Renovascular - etiology ; Hypertension, Renovascular - metabolism ; Hypertension, Renovascular - therapy ; Male ; Medical sciences ; Norepinephrine ; Norepinephrine - metabolism ; Oxidopamine ; Rats ; Rats, Inbred Strains ; Renin - blood ; Sympathectomy ; Sympathectomy, Chemical ; Sympathetic Nervous System - physiology</subject><ispartof>Clinical and experimental hypertension (1993), 1984, Vol.A6 (5), p.1011-1026</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-ef23ebf24bfe288c1a7581861c3b86f5a969a8d17f410cab9557aa1e1ae1d4dc3</citedby><cites>FETCH-LOGICAL-c430t-ef23ebf24bfe288c1a7581861c3b86f5a969a8d17f410cab9557aa1e1ae1d4dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10641968409044053$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10641968409044053$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4023,27922,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8984770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6428783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurnjek, María Luisa</creatorcontrib><creatorcontrib>Basso, Nidia</creatorcontrib><creatorcontrib>Taquini, Alberto C.</creatorcontrib><title>Neonatal 6-Hydroxydopamine Treatment and the Development of Renal Hypertension in the Rat</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens A</addtitle><description>The onset and development of 2 kidney-2 clip renal hypertension was studied in chronically sympathectomized rats treated with 6-hydroxy-dopamine (6-OHDA) immediately after birth and with adrenal demedullation performed at the time of clipping. Blood pressure (BP) was lower in 6-OHDA treated animals than in untreated controls and the rate of hypertension development was similar in both groups. Urinary excretion of norepinephrine (NE) was significantly decreased during the 15th week and normal by the end of the 20th week. The cardiac NE content reached negligible levels while the mesenteric arteries retained 50% of its content. In the central nervous system (CNS) the 6-OHDA treatment induced a significant increase in NE concentration in the brain stem and medulla oblongata and a significant decrease in cerebellum. Hypertension produced a significant decrease in NE content in the brain stem while 6-OHDA treatment in hypertensive rats resulted in a generalized NE depletion in all the CNS areas. Results have shown that 6-OHDA treatment does not produce a complete and generally distributed sympathectomy; treatment reduces the level of BP but does not change the slope in BP increase.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Brain - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Catecholamines</subject><subject>Epinephrine</subject><subject>Experimental diseases</subject><subject>Hydroxydopamines</subject><subject>Hypertension, Renovascular - etiology</subject><subject>Hypertension, Renovascular - metabolism</subject><subject>Hypertension, Renovascular - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Oxidopamine</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Renin - blood</subject><subject>Sympathectomy</subject><subject>Sympathectomy, Chemical</subject><subject>Sympathetic Nervous System - physiology</subject><issn>1064-1963</issn><issn>0730-0077</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFTEUhgdRaq3-ABfCLMTd2JxJJpNBN1I_bqFUKHXhajiTOeFOySRjkqvOvzf2XgtS6Coh7_MckjdF8RLYWw6sOwUmBXRSCdYxIVjDHxXH0NRNJRmTj_M-51UG-NPiWYw3jIGQjToqjqSoVav4cfH9krzDhLaU1WYdg_-9jn7BeXJUXgfCNJNLJbqxTFsqP9JPsn65PfOmvCKXxc26UEjk4uRdOblb8ArT8-KJQRvpxWE9Kb59_nR9tqkuvn45P_twUWnBWarI1JwGU4vBUK2UBmwbBUqC5oOSpsFOdqhGaI0ApnHomqZFBAIkGMWo-UnxZj93Cf7HjmLq5ylqshYd-V3sFQAw0fIMwh7UwccYyPRLmGYMaw-s_1tnf6_O7Lw6DN8NM413xqG_nL8-5Bg1WhPQ6SneYapTom1Zxt7vsckZH2b85YMd-4Sr9eGfwx-6xbv_9C2hTVuNgfobvwv5E-IDb_gDtL2iXQ</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Kurnjek, María Luisa</creator><creator>Basso, Nidia</creator><creator>Taquini, Alberto C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Neonatal 6-Hydroxydopamine Treatment and the Development of Renal Hypertension in the Rat</title><author>Kurnjek, María Luisa ; Basso, Nidia ; Taquini, Alberto C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-ef23ebf24bfe288c1a7581861c3b86f5a969a8d17f410cab9557aa1e1ae1d4dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Brain - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Catecholamines</topic><topic>Epinephrine</topic><topic>Experimental diseases</topic><topic>Hydroxydopamines</topic><topic>Hypertension, Renovascular - etiology</topic><topic>Hypertension, Renovascular - metabolism</topic><topic>Hypertension, Renovascular - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Oxidopamine</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Renin - blood</topic><topic>Sympathectomy</topic><topic>Sympathectomy, Chemical</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurnjek, María Luisa</creatorcontrib><creatorcontrib>Basso, Nidia</creatorcontrib><creatorcontrib>Taquini, Alberto C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurnjek, María Luisa</au><au>Basso, Nidia</au><au>Taquini, Alberto C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal 6-Hydroxydopamine Treatment and the Development of Renal Hypertension in the Rat</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens A</addtitle><date>1984</date><risdate>1984</risdate><volume>A6</volume><issue>5</issue><spage>1011</spage><epage>1026</epage><pages>1011-1026</pages><issn>1064-1963</issn><issn>0730-0077</issn><eissn>1525-6006</eissn><coden>CEHADM</coden><abstract>The onset and development of 2 kidney-2 clip renal hypertension was studied in chronically sympathectomized rats treated with 6-hydroxy-dopamine (6-OHDA) immediately after birth and with adrenal demedullation performed at the time of clipping. Blood pressure (BP) was lower in 6-OHDA treated animals than in untreated controls and the rate of hypertension development was similar in both groups. Urinary excretion of norepinephrine (NE) was significantly decreased during the 15th week and normal by the end of the 20th week. The cardiac NE content reached negligible levels while the mesenteric arteries retained 50% of its content. In the central nervous system (CNS) the 6-OHDA treatment induced a significant increase in NE concentration in the brain stem and medulla oblongata and a significant decrease in cerebellum. Hypertension produced a significant decrease in NE content in the brain stem while 6-OHDA treatment in hypertensive rats resulted in a generalized NE depletion in all the CNS areas. Results have shown that 6-OHDA treatment does not produce a complete and generally distributed sympathectomy; treatment reduces the level of BP but does not change the slope in BP increase.</abstract><cop>Basel</cop><cop>Hong Kong</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>6428783</pmid><doi>10.3109/10641968409044053</doi><tpages>16</tpages></addata></record> |
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| ispartof | Clinical and experimental hypertension (1993), 1984, Vol.A6 (5), p.1011-1026 |
| issn | 1064-1963 0730-0077 1525-6006 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Brain - metabolism Cardiology. Vascular system Catecholamines Epinephrine Experimental diseases Hydroxydopamines Hypertension, Renovascular - etiology Hypertension, Renovascular - metabolism Hypertension, Renovascular - therapy Male Medical sciences Norepinephrine Norepinephrine - metabolism Oxidopamine Rats Rats, Inbred Strains Renin - blood Sympathectomy Sympathectomy, Chemical Sympathetic Nervous System - physiology |
| title | Neonatal 6-Hydroxydopamine Treatment and the Development of Renal Hypertension in the Rat |
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