Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by α-difluoromethylornithine

Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. The relevance of these TPA-induced changes to the mechanism of tumor prom...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1983-08, Vol.43 (8), p.3732-3738
Hauptverfasser:	TAKIGAWA, M, VERMA, A. K, SIMSIMAN, R. C, BOUTWELL, R. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - metabolism Administration, Oral Administration, Topical Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Chemotherapy Eflornithine Epidermis - drug effects Epidermis - metabolism Female Injections, Intraperitoneal Medical sciences Mice Ornithine - administration & dosage Ornithine - analogs & derivatives Ornithine - pharmacology Ornithine Decarboxylase - metabolism Pharmacology. Drug treatments Polyamines - biosynthesis Skin Neoplasms - chemically induced Tetradecanoylphorbol Acetate
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!