The Membranous Epithelial (M) Cell and the Mucosal Immune System
Membranous epithelial (M) cells are specialized epithelial cells overlying the subepithelial lymphoid follicles in the gastrointestinal and respiratory tracts. Antigens, including some viruses and bacteria, penetrate the mucosal barrier via the M cell, which endocytoses and transports antigens and m...
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| Veröffentlicht in: | Annual review of medicine 1984, Vol.35 (1), p.95-112 |
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| container_title | Annual review of medicine |
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| creator | Wolf, J L Bye, W A |
| description | Membranous epithelial (M) cells are specialized epithelial cells overlying the subepithelial lymphoid follicles in the gastrointestinal and respiratory tracts. Antigens, including some viruses and bacteria, penetrate the mucosal barrier via the M cell, which endocytoses and transports antigens and microorganisms into the Peyer's patch or bronchial-associated lymphoid tissue. Here antigens may initiate an immune response and/or disseminate and induce disease. This review discusses the structure and function of the M cell, its role in macromolecular uptake, and its interaction with the immune system. |
| doi_str_mv | 10.1146/annurev.me.35.020184.000523 |
| format | Article |
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Antigens, including some viruses and bacteria, penetrate the mucosal barrier via the M cell, which endocytoses and transports antigens and microorganisms into the Peyer's patch or bronchial-associated lymphoid tissue. Here antigens may initiate an immune response and/or disseminate and induce disease. This review discusses the structure and function of the M cell, its role in macromolecular uptake, and its interaction with the immune system.</description><identifier>ISSN: 0066-4219</identifier><identifier>EISSN: 1545-326X</identifier><identifier>DOI: 10.1146/annurev.me.35.020184.000523</identifier><identifier>PMID: 6372677</identifier><identifier>CODEN: ARMCAH</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibody Formation ; Biological and medical sciences ; Biological Transport ; Epithelial Cells ; Epithelium - metabolism ; Epithelium - ultrastructure ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastric Mucosa - cytology ; Gastric Mucosa - immunology ; Gastric Mucosa - metabolism ; Humans ; Immunobiology ; Intestinal Mucosa - cytology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - ultrastructure ; Lymphoid Tissue - cytology ; Lymphoid Tissue - immunology ; Lymphoid Tissue - metabolism ; Mucous Membrane - immunology ; Mucous Membrane - metabolism ; Organs and cells involved in the immune response ; Peyer's Patches - immunology ; Peyer's Patches - metabolism ; Respiratory System - cytology ; Respiratory System - immunology ; Respiratory System - metabolism</subject><ispartof>Annual review of medicine, 1984, Vol.35 (1), p.95-112</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a414t-8a9031c9977b2fbe689b28b90b9f6dac6c60ca3dcfa12edad5a58cfe895cdabc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.me.35.020184.000523?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.me.35.020184.000523$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4010,4168,27900,27901,27902,77997,77998</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8995002$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6372677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolf, J L</creatorcontrib><creatorcontrib>Bye, W A</creatorcontrib><title>The Membranous Epithelial (M) Cell and the Mucosal Immune System</title><title>Annual review of medicine</title><addtitle>Annu Rev Med</addtitle><description>Membranous epithelial (M) cells are specialized epithelial cells overlying the subepithelial lymphoid follicles in the gastrointestinal and respiratory tracts. Antigens, including some viruses and bacteria, penetrate the mucosal barrier via the M cell, which endocytoses and transports antigens and microorganisms into the Peyer's patch or bronchial-associated lymphoid tissue. Here antigens may initiate an immune response and/or disseminate and induce disease. This review discusses the structure and function of the M cell, its role in macromolecular uptake, and its interaction with the immune system.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Epithelial Cells</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastric Mucosa - cytology</subject><subject>Gastric Mucosa - immunology</subject><subject>Gastric Mucosa - metabolism</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - metabolism</subject><subject>Mucous Membrane - immunology</subject><subject>Mucous Membrane - metabolism</subject><subject>Organs and cells involved in the immune response</subject><subject>Peyer's Patches - immunology</subject><subject>Peyer's Patches - metabolism</subject><subject>Respiratory System - cytology</subject><subject>Respiratory System - immunology</subject><subject>Respiratory System - metabolism</subject><issn>0066-4219</issn><issn>1545-326X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1L5TAUhoOM6B31JwgFh2FctOajSRNmc-Wio6C4UMFdOE1PsdL0Xpt2xH9vLi1uxVUW73PyvjyEnDCaMZarM-i6scf_mcdMyIxyynSeUUolFztkwWQuU8HV0w-yoFSpNOfM7JOfIbxExgih98ieEgVXRbEgy4dnTG7Rlz106zEkF5tmeMa2gTb5c3uarLBtE-iqZNhio1uHGFx7P3aY3L-HAf0h2a2hDXg0vwfk8fLiYXWV3tz9u16d36SQs3xINRgqmDOmKEpel6i0KbkuDS1NrSpwyinqQFSuBsaxgkqC1K5GbaSroHTigPye_t3069cRw2B9E1ycBx3G4VYzKrXg8kuQxT2qyEUE_06g69ch9FjbTd946N8to3Yr2s6irUcrpJ1E20l0vD6ea8bSY_V5O5uN-a85h-CgraNf14RPTBsjKeURW07Ytgva2NbgW_jWkg-jzp7G</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Wolf, J L</creator><creator>Bye, W A</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>The Membranous Epithelial (M) Cell and the Mucosal Immune System</title><author>Wolf, J L ; Bye, W A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a414t-8a9031c9977b2fbe689b28b90b9f6dac6c60ca3dcfa12edad5a58cfe895cdabc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Epithelial Cells</topic><topic>Epithelium - metabolism</topic><topic>Epithelium - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gastric Mucosa - cytology</topic><topic>Gastric Mucosa - immunology</topic><topic>Gastric Mucosa - metabolism</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphoid Tissue - metabolism</topic><topic>Mucous Membrane - immunology</topic><topic>Mucous Membrane - metabolism</topic><topic>Organs and cells involved in the immune response</topic><topic>Peyer's Patches - immunology</topic><topic>Peyer's Patches - metabolism</topic><topic>Respiratory System - cytology</topic><topic>Respiratory System - immunology</topic><topic>Respiratory System - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolf, J L</creatorcontrib><creatorcontrib>Bye, W A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolf, J L</au><au>Bye, W A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Membranous Epithelial (M) Cell and the Mucosal Immune System</atitle><jtitle>Annual review of medicine</jtitle><addtitle>Annu Rev Med</addtitle><date>1984</date><risdate>1984</risdate><volume>35</volume><issue>1</issue><spage>95</spage><epage>112</epage><pages>95-112</pages><issn>0066-4219</issn><eissn>1545-326X</eissn><coden>ARMCAH</coden><abstract>Membranous epithelial (M) cells are specialized epithelial cells overlying the subepithelial lymphoid follicles in the gastrointestinal and respiratory tracts. Antigens, including some viruses and bacteria, penetrate the mucosal barrier via the M cell, which endocytoses and transports antigens and microorganisms into the Peyer's patch or bronchial-associated lymphoid tissue. Here antigens may initiate an immune response and/or disseminate and induce disease. This review discusses the structure and function of the M cell, its role in macromolecular uptake, and its interaction with the immune system.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>6372677</pmid><doi>10.1146/annurev.me.35.020184.000523</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4219 |
| ispartof | Annual review of medicine, 1984, Vol.35 (1), p.95-112 |
| issn | 0066-4219 1545-326X |
| language | eng |
| recordid | cdi_pubmed_primary_6372677 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Antibody Formation Biological and medical sciences Biological Transport Epithelial Cells Epithelium - metabolism Epithelium - ultrastructure Fundamental and applied biological sciences. Psychology Fundamental immunology Gastric Mucosa - cytology Gastric Mucosa - immunology Gastric Mucosa - metabolism Humans Immunobiology Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - ultrastructure Lymphoid Tissue - cytology Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Mucous Membrane - immunology Mucous Membrane - metabolism Organs and cells involved in the immune response Peyer's Patches - immunology Peyer's Patches - metabolism Respiratory System - cytology Respiratory System - immunology Respiratory System - metabolism |
| title | The Membranous Epithelial (M) Cell and the Mucosal Immune System |
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