99mTc-Pertechnetate Uptake Measurement in the Rabbit Knee-Joint: II. Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints
The kinetics of 99mTechnetium pertechnetate (99m TcO−) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 1983, Vol.12 (1), p.59-63 |
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| container_end_page | 63 |
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| container_title | Scandinavian journal of rheumatology |
| container_volume | 12 |
| creator | Van Beusekom, Henk J. Van De Putte, Levinus B. A. Buijs, Wil C. A. M. Van Den Broek, Wim J. M. Van Den Berg, Wim B. |
| description | The kinetics of 99mTechnetium pertechnetate (99m TcO−) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In both inflamed and non-inflamed joints, a rapid increase in radioactivity was followed by a plateau lasting for at least one hour. The time needed to reach 95% of the plateau count rate (tp) was significantly increased in inflamed as compared with non-inflamed knee-joints. Moreover, tp values were significantly higher in acutely than in chronically inflamed joints. No correlation was found between 99mTcO− uptake and tp values. The study of kinetics of 99mTcO− in the rabbit knee-joint provides information additional to quantitation of inflammation by 99mTcO4 uptake measurements, since kinetic data characterize the type of joint inflammation. |
| doi_str_mv | 10.3109/03009748309102006 |
| format | Article |
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Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Van Beusekom, Henk J. ; Van De Putte, Levinus B. A. ; Buijs, Wil C. A. M. ; Van Den Broek, Wim J. M. ; Van Den Berg, Wim B.</creator><creatorcontrib>Van Beusekom, Henk J. ; Van De Putte, Levinus B. A. ; Buijs, Wil C. A. M. ; Van Den Broek, Wim J. M. ; Van Den Berg, Wim B.</creatorcontrib><description>The kinetics of 99mTechnetium pertechnetate (99m TcO−) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In both inflamed and non-inflamed joints, a rapid increase in radioactivity was followed by a plateau lasting for at least one hour. The time needed to reach 95% of the plateau count rate (tp) was significantly increased in inflamed as compared with non-inflamed knee-joints. Moreover, tp values were significantly higher in acutely than in chronically inflamed joints. No correlation was found between 99mTcO− uptake and tp values. The study of kinetics of 99mTcO− in the rabbit knee-joint provides information additional to quantitation of inflammation by 99mTcO4 uptake measurements, since kinetic data characterize the type of joint inflammation.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.3109/03009748309102006</identifier><identifier>PMID: 6300997</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Arthritis - diagnostic imaging ; Arthritis - metabolism ; Knee Joint - diagnostic imaging ; Knee Joint - metabolism ; Rabbits ; Radionuclide Imaging ; Sodium Pertechnetate Tc 99m ; Technetium - metabolism</subject><ispartof>Scandinavian journal of rheumatology, 1983, Vol.12 (1), p.59-63</ispartof><rights>1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03009748309102006$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03009748309102006$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4022,27922,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6300997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Beusekom, Henk J.</creatorcontrib><creatorcontrib>Van De Putte, Levinus B. A.</creatorcontrib><creatorcontrib>Buijs, Wil C. A. M.</creatorcontrib><creatorcontrib>Van Den Broek, Wim J. M.</creatorcontrib><creatorcontrib>Van Den Berg, Wim B.</creatorcontrib><title>99mTc-Pertechnetate Uptake Measurement in the Rabbit Knee-Joint: II. Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>The kinetics of 99mTechnetium pertechnetate (99m TcO−) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In both inflamed and non-inflamed joints, a rapid increase in radioactivity was followed by a plateau lasting for at least one hour. The time needed to reach 95% of the plateau count rate (tp) was significantly increased in inflamed as compared with non-inflamed knee-joints. Moreover, tp values were significantly higher in acutely than in chronically inflamed joints. No correlation was found between 99mTcO− uptake and tp values. The study of kinetics of 99mTcO− in the rabbit knee-joint provides information additional to quantitation of inflammation by 99mTcO4 uptake measurements, since kinetic data characterize the type of joint inflammation.</description><subject>Animals</subject><subject>Arthritis - diagnostic imaging</subject><subject>Arthritis - metabolism</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - metabolism</subject><subject>Rabbits</subject><subject>Radionuclide Imaging</subject><subject>Sodium Pertechnetate Tc 99m</subject><subject>Technetium - metabolism</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1TAQhS0EKpfCA7BA8opdyjhx_ANsqoqfSwtFqF1Hk2Si-JI4F9sR6gsg1jwiT0JC76ZCLEazOOc70pxh7KmAk0KAfQEFgNXSFGAF5ADqHtuIEvJM6yK_zzarni2G_CF7FOMOAKTV9ogdqRW0esN-WDteNdlnComa3lPCRPx6n_Ar8Y-EcQ40kk_ceZ564l-wrl3i554o-zA5n17y7faEn7uFdE3kU8f_Bl7-_vlLrtCnKYw4cPQtPw2pD26x3UnZrSnxMXvQ4RDpyWEfs-u3b67O3mcXl--2Z6cXmROl0VluQEsrukLbwtRStaLFEkuFKFswptGqEUoK0-alLK0ou1aRRRJKQ20AiuKYPb_N3Yfp20wxVaOLDQ0DeprmWBmQuVLaLMZnB-Ncj9RW--BGDDfVobhFf32rO9-tJ36fwtBWCW-GKXQBfeNitbxoHVv986YFf3UH7wmH1DcYqNpNc_BLB9X_6T9CQpRR</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Van Beusekom, Henk J.</creator><creator>Van De Putte, Levinus B. A.</creator><creator>Buijs, Wil C. A. M.</creator><creator>Van Den Broek, Wim J. M.</creator><creator>Van Den Berg, Wim B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>99mTc-Pertechnetate Uptake Measurement in the Rabbit Knee-Joint: II. Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints</title><author>Van Beusekom, Henk J. ; Van De Putte, Levinus B. A. ; Buijs, Wil C. A. M. ; Van Den Broek, Wim J. M. ; Van Den Berg, Wim B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1587-2807491f37938b46d1da5a56aa4d088c76c16418d2545915fd6e9ae1670b80033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Arthritis - diagnostic imaging</topic><topic>Arthritis - metabolism</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - metabolism</topic><topic>Rabbits</topic><topic>Radionuclide Imaging</topic><topic>Sodium Pertechnetate Tc 99m</topic><topic>Technetium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Beusekom, Henk J.</creatorcontrib><creatorcontrib>Van De Putte, Levinus B. A.</creatorcontrib><creatorcontrib>Buijs, Wil C. A. M.</creatorcontrib><creatorcontrib>Van Den Broek, Wim J. M.</creatorcontrib><creatorcontrib>Van Den Berg, Wim B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Beusekom, Henk J.</au><au>Van De Putte, Levinus B. A.</au><au>Buijs, Wil C. A. M.</au><au>Van Den Broek, Wim J. M.</au><au>Van Den Berg, Wim B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>99mTc-Pertechnetate Uptake Measurement in the Rabbit Knee-Joint: II. Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>1983</date><risdate>1983</risdate><volume>12</volume><issue>1</issue><spage>59</spage><epage>63</epage><pages>59-63</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><abstract>The kinetics of 99mTechnetium pertechnetate (99m TcO−) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In both inflamed and non-inflamed joints, a rapid increase in radioactivity was followed by a plateau lasting for at least one hour. The time needed to reach 95% of the plateau count rate (tp) was significantly increased in inflamed as compared with non-inflamed knee-joints. Moreover, tp values were significantly higher in acutely than in chronically inflamed joints. No correlation was found between 99mTcO− uptake and tp values. The study of kinetics of 99mTcO− in the rabbit knee-joint provides information additional to quantitation of inflammation by 99mTcO4 uptake measurements, since kinetic data characterize the type of joint inflammation.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>6300997</pmid><doi>10.3109/03009748309102006</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9742 |
| ispartof | Scandinavian journal of rheumatology, 1983, Vol.12 (1), p.59-63 |
| issn | 0300-9742 1502-7732 |
| language | eng |
| recordid | cdi_pubmed_primary_6300997 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Arthritis - diagnostic imaging Arthritis - metabolism Knee Joint - diagnostic imaging Knee Joint - metabolism Rabbits Radionuclide Imaging Sodium Pertechnetate Tc 99m Technetium - metabolism |
| title | 99mTc-Pertechnetate Uptake Measurement in the Rabbit Knee-Joint: II. Kinetics of 99mTcO−4 in Normal and Arthritic Rabbit Knee-joints |
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